Regular ArticleCYP12A1, a Mitochondrial Cytochrome P450 from the House Fly☆,☆☆
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2022, Pesticide Biochemistry and PhysiologyCitation Excerpt :In contrast, P450s that are involved either in known physiological functions, such as regulation of synthesis and degradation of endogenous compounds (Fig. 2A, genes decorated with black triangles), or are suspected to be involved in some physiological function (Fig. 2A, black/red stars) are found in all four clans. It should be noted, however, that there are P450s in other clans that are involved in detoxification in non-Lepidoptera species as in case of the mitochondrial CYP12A1 of M. domestica (Guzov et al., 1998). Similarly, in the hymenopterans, the detoxification-related P450s are found in Clan 3 (Fig. 2B, genes with black circles) and more specifically in one of two families; CYP9Q/CYP9BU (neonicotinoids, pyrethroids, quercetin) (Beadle et al., 2019; Mao et al., 2011; Troczka et al., 2019), or CYP6AS (quercetin) (Mao et al., 2009).
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The sequence data are deposited in GenBank under the Accession Nos. U86618 (CYP12A1), U94698 (CYP12A2), and U94699 (CYP12A3).
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Omura, T.Ishimura, Y.Fuji-Kuriyama, Y.
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Present address: Monsanto Company, 700 Chesterfield Parkway North, St. Louis, MO 63198.
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To whom correspondence should be addressed at Department of Entomology, University of Arizona, Forbes 410, PO Box 210036, Tucson, AZ 85721-0036. Fax: (520) 626-8058; E-mail:[email protected].