Biochemical and Biophysical Research Communications
Volume 216, Issue 2, 13 November 1995, Pages 452-457
Regular ArticleMutations of the Transforming Growth Factor-β Type II Receptor Gene and Genomic Instability in Hereditary Nonpolyposis Colorectal Cancer
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Cited by (105)
Epithelial-mesenchymal transition in cancer metastasis: Mechanisms, markers and strategies to overcome drug resistance in the clinic
2009, Biochimica et Biophysica Acta - Reviews on CancerSignificance of mutations in TGFBR2 and BAX in neoplastic progression and patient outcome in sporadic colorectal tumors with high-frequency microsatellite instability
2005, Cancer Genetics and CytogeneticsCitation Excerpt :Mutations at codon 12 of the KRAS gene (also known as K-ras) were detected by means of enriched restriction fragment length polymorphism-polymerase chain reaction (RFLP-PCR) as previously described by Kahn et al. [21], with minor modifications [22]. To examine frameshift mutations in the TGFBR2 gene, we used PCR-single-strand conformation polymorphism (PCR-SSCP) to analyze an intronic mononucleotide repeat sequence (A)10, following the conditions published previously [23]. We also amplified a 94-pair region containing a tract of (G)8 in the third exon (codons 38–41) of the BAX gene; the primer sequences and conditions used are described elsewhere [14].
Identification of genetic alterations in the TGFβ type II receptor gene promoter
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