Biochemical and Biophysical Research Communications
Regular ArticlePhenol Sulfotransferase Pharmacogenetics in Humans: Association of CommonSULT1A1Alleles with TS PST Phenotype☆
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Quinoline is more genotoxic than 4-methylquinoline in hiHeps cells and rodent liver
2023, Mutation Research - Genetic Toxicology and Environmental MutagenesisImpacts of 119 missense variants at functionally important sites of drug-metabolizing human cytosolic sulfotransferase SULT1A1: An in silico study
2022, Informatics in Medicine UnlockedCitation Excerpt :Among these closely related enzymes, SULT1A1 is the major phenol sulfotransferase in the liver, and has high affinities for a wide range of substrates [6]. This 295 amino acid-long enzyme is also expressed in many other tissues including brain, gastrointestinal tract, platelets and placenta [7]. Some common substrates for the SULT1A1 include simple phenolic compounds like para-nitrophenol (or 4-nitrophenol, PNP) [8,9]; drugs like acetaminophen [10], minoxidil (a drug for stimulating hair growth) [11]; steroid hormones like estrone, β-estradiol [12], 2-hydroxyestrone, 2-hydroxyestradiol, 4-hydroxyestrone, 4-hydroxyestradiol [13]; synthetic estrogenic compounds like trans-4-hydroxytamoxifen [14], diethylstilbestrol [12], 2-methoxy estradiol [15], quinoline [16], and others [17].
Effects of the human SULT1A1 polymorphisms on the sulfation of acetaminophen,O-desmethylnaproxen, and tapentadol
2019, Pharmacological ReportsSulfotransferases
2018, Comprehensive Toxicology: Third EditionRelationship of SULT1A1 copy number variation with estrogen metabolism and human health
2017, Journal of Steroid Biochemistry and Molecular Biology
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Supported in part by NIH Grants RO1 GM 28157 (R.M.W.) and RO1 GM 35720 (R.M.W.), by a supplement to RO1 GM 35720 supported by the Office of Research on Women's Health (R.M.W.), and by an NRSA (NIH) Individual Postdoctoral Fellowship (R.B.R.).
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