Regular ArticlePeroxisomal Disease Cell Lines with Cellular Plasmalogen Deficiency Have Impaired Muscarinic Cholinergic Signal Transduction Activity and Amyloid Precursor Protein Secretion☆
References (32)
- et al.
Mech. Ageing Dev.
(1995) - et al.
Biochimie
(1995) - et al.
Mech. Ageing Dev.
(1996) - et al.
J. Lipid Res.
(1995) - et al.
Brain Res.
(1995) - et al.
TINS
(1995) - et al.
Biochem. Biophys. Res. Commun.
(1995) - et al.
J. Pediatr.
(1995) - et al.
J. Biol. Chem.
(1995) - et al.
J. Biol. Chem.
(1988)
Chem. Physics Lipids
Brain Res. Rev.
Lipids
Ann. N.Y. Acad. Sci.
Cited by (34)
Roles of endogenous ether lipids and associated PUFAs in the regulation of ion channels and their relevance for disease
2020, Journal of Lipid ResearchCitation Excerpt :This study suggests that ELs can modulate the lipid environment of ion channels and therefore regulate their activities. Moreover, ELs take part in cholinergic transmission, and a decrease of muscarinic-GTPase coupling has been observed in Pl-deficient cell lines, which decreases physiological amyloid precursor protein synthesis (36). Glutamatergic transmission is also affected by ELs and in synaptosomal preparations from DHAP acyltransferase (DHAPAT; an enzyme of EL biosynthesis) KO mice, calcium-dependent glutamate and acetylcholine releases are weaker than in controls (21).
The YhhN protein of Legionella pneumophila is a Lysoplasmalogenase
2015, Biochimica et Biophysica Acta - BiomembranesCitation Excerpt :At submicellar concentrations, lysoplasmalogens affect the dynamics of cell membranes by increasing membrane fluidity [14]. They have specific effects on several transmembrane proteins, such as inhibition of cholinergic signal transduction [15], inhibition of Na-K-ATPase [16], and activation of cAMP-dependent protein kinase C [17]. Lysoplasmalogens also serve as self antigens that stimulate invariant natural killer T cells in the thymus [18].
Lipids of mitochondria
2013, Progress in Lipid ResearchCitation Excerpt :This structure leads to strong lipophilic properties and allows plasmalogens to form inverse hexagonal phase structures, thereby favoring membrane fusion [18,19]. Depending on the tissue, plasmalogens are important for the function of transmembrane proteins and membrane-related intracellular and extracellular cholesterol transport [19–22]. Mammalian cells and cell lines like Morris hepatoma, Zajdela hepatoma, Hepatoma from rat and mouse and Fibroblasts (mouse, BHK) contain sphingolipids in the range of 1–12% of total phospholipids, whereas mitochondria of microorganisms and plants are devoid of this lipid class (for recent review see Ref. [23]).
Functions of plasmalogen lipids in health and disease
2012, Biochimica et Biophysica Acta - Molecular Basis of DiseaseCitation Excerpt :Membrane signaling defects have also been demonstrated. Perichon et al. [56], using fibroblasts from RCDP1 and Zellweger patients, as well as AGPS deficient CHO cells showed decreased muscarinic cholinergic signal transduction, measured by carbachol induction of low-Km GTPase activity and reduced amyloid precursor protein (APP) secretion. All protein subunits of the GTPase were intact and APP levels were otherwise normal, indicating a specific membrane defect in these cell lines.
Plasmalogens, platelet-activating factor, and other ether glycerophospholipids
2012, Bioactive LipidsPlasmalogens the neglected regulatory and scavenging lipid species
2011, Chemistry and Physics of LipidsCitation Excerpt :The importance of plasmalogens in cellular membranes has been extensively studied in plasmalogen deficient cells. These cells exhibit decreased transmembrane protein function (Perichon et al., 1998) and decreased membrane-related intracellular (Munn et al., 2003) and extra cellular (Mandel et al., 1998) cholesterol transport. Impaired membrane traffic has also been observed in defective ether lipid biosynthesis (Thai et al., 2001) and vesicular fusion seems to be especially sensitive to the amount and type of PE plasmalogens in the membrane.
- ☆
Scriver, C. R.Beaudet, A. L.Sly, W. S.Valle, D.