Regular ArticleHigh Levels of Ezrin Expressed by Human Pancreatic Adenocarcinoma Cell Lines with High Metastatic Potential
References (26)
- et al.
Curr. Opin. Cell. Biol.
(1997) - et al.
Curr. Opin. Cell. Biol.
(1997) - et al.
J. Biol. Chem.
(1998) - et al.
Curr. Opin. Cell Biol.
(1994) - et al.
Cell
(1991) - et al.
J. Cell. Biol.
(1998) - et al.
J. Cell. Biol.
(1994) - et al.
EMBO J.
(1989) - et al.
Oncogene
(1993) - et al.
J. Cell. Biol.
(1996)
J. Cell Sci.
J. Cell. Biol.
Cited by (136)
Ezrin gone rogue in cancer progression and metastasis: An enticing therapeutic target
2022, Biochimica et Biophysica Acta - Reviews on CancerCircARHGAP12 promotes nasopharyngeal carcinoma migration and invasion via ezrin-mediated cytoskeletal remodeling
2021, Cancer LettersCitation Excerpt :Cell movement and migration require dynamic cytoskeletal remodeling, including the dynamic assembly of microtubules, microfilaments, and intermediate filaments, as well as assistance from cytoskeleton-related proteins to change the 3D structure and morphology of cells and drive movement. Cytoskeletal remodeling also plays important roles in cell division, intracellular transport, and maintaining cell shape [38–40]. EZR is a member of the ezrin/radixin/moesin protein family that acts as a linker between the plasma membrane and actin.
Phosphorylated Ezrin (Thr567) Regulates Hippo Pathway and Yes-Associated Protein (Yap) in Liver
2020, American Journal of PathologyEzrin protein overexpression predicts the poor prognosis of pancreatic ductal adenocarcinomas
2015, Experimental and Molecular PathologyCitation Excerpt :Ezrin is the best characterized member in the ERM family; it links to aggressive tumor behavior through the involvement in the metastatic process, such as cell adhesion, cell survival, cell motility, and signal transduction, all of which are important for tumor development and progression (Bruce et al., 2007; Guo et al., 2008; Tudor et al., 2014). Accumulating evidences suggest that ezrin is deregulated in borderline lesions and overexpression of ezrin associated with malignancy and metastatic potential of tumors (Yeh et al., 2005; Kitamura et al., 2000; Akisawa et al., 1999), and also indicated that malignant tumors with ezrin overexpression were more invasive with poor-differentiation, rapid progress, early metastasis and poor prognosis (Mallikarjuna et al., 2007; Hara et al., 2008). Recently, researchers have found that ezrin was overexpressed in pancreatic cancer and had significant correlation with its malignance (Clucas et al., 2014; Capello et al., 2013; Kawahara et al., 2013).
Design, synthesis and biological evaluation of ezrin inhibitors targeting metastatic osteosarcoma
2014, Bioorganic and Medicinal Chemistry
- 1
To whom correspondence should be addressed. Fax: (402) 559-4651.