Regular ArticleIdentification of Three Alternatively Spliced Variants of Human CD28 mRNA
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CD28 gene polymorphisms and acute cellular rejection after liver transplantation
2020, Human ImmunologyPotentiating functional antigen-specific CD8<sup>+</sup> T cell immunity by a novel PD1 isoform-based fusion DNA vaccine
2013, Molecular TherapyCitation Excerpt :Interestingly, Δ42PD1 mRNA is preferentially expressed in monocytes, macrophages, NKT, and NK cells as compared with DCs, B cells, and T cells (Figure 1d). This phenomenon has not been reported for PD1 or spliced variants of other CD28 family members such as CTLA-4 and CD28.14,15,22 Whether this has any biological relevance is yet to be determined.
Increased production of circulating soluble co-stimulatory molecules CTLA-4, CD28 and CD80 in patients with rheumatoid arthritis
2012, International ImmunopharmacologyCitation Excerpt :Elevation of serum sCD28 in RA may reflect an upregulation of mCD28 expression on T cells that indicated the activation of APC and T cells. Previous in vitro studies have demonstrated that APC such as dendritic cells could be induced by sCD28 to express IL-6 and IFN-γ [30]. Besides, sCD28 may also act as inhibitory molecules by competing and interfering with the interactions between CTLA-4/CD28 and B7 molecules of APC [31].
Identification of CD3e{open}, CD4, CD8β splice variants of Atlantic salmon
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2011, Fish and Shellfish ImmunologyAberrant production of soluble co-stimulatory molecules CTLA-4 and CD28 in patients with chronic hepatitis B
2011, Microbial PathogenesisCitation Excerpt :The aberrant production of soluble co-stimulatory molecules CTLA-4 and CD28 should be related, at least partly, to the pathogenesis and severity of chronic HBV infection, which occurs by the dysregulation of T cell co-stimulation. sCD28 could be produced either by shedding of the membrane form or from alternative mRNA splicing, but the presence of sCD28 in the blood circulation is more likely due to the shedding of the membrane form [35]. sCTLA-4 mRNA has been demonstrated to be constitutively expressed on non-activated T cells, and its expression is reduced upon stimulation [24].
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G.M. and P.J. are equivalent contributors.
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Corresponding author. Centre d'Immunologie Pierre Fabre, 5, avenue Napoléon III, F-74164 Saint Julien en Genevois. Fax: +33 4 50 35 35 90. E-mail:[email protected].