Regular ArticleGenomic Organization and Chromosomal Localization of the Human CD163 (M130) Gene: A Member of the Scavenger Receptor Cysteine-Rich Superfamily☆,☆☆
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2022, VirologyCitation Excerpt :Porcine CD163, which serves as a cellular entry receptor for PRRSV, is a type I transmembrane protein that belongs to the class B of the scavenger receptor cysteine-rich (SRCR) superfamily (SRCR-SF) (Fabriek et al., 2005, 2007; Law et al., 1993; Ritter et al., 1999; Su et al., 2021). CD163 is an endocytic receptor expressed exclusively in cells of the monocyte-macrophage lineage (Law et al., 1993; Ritter et al., 1999). CD163-positive macrophages, specially porcine alveolar macrophages (PAMs), are the PRRSV main target cells in vivo (Duan et al., 1997).
Post-transcriptional regulation through alternative splicing in the lungs of Tibetan pigs under hypoxia
2022, GeneCitation Excerpt :CD163 generates all five AS types, and several other genes, including SLC25A29, SNAPC1, OBSL1, OBSCN, MKI67, IL1A and NDRG2, have four types of AS events. Our analysis indicates that AS plays an indispensable role in producing different proteins and transcripts to affect the lungs in the regulation of gene expression during hypoxia (Ritter et al., 1999). Hypoxia can regulate the AS of hypoxia-induced genes and genes whose transcription is not changed by hypoxia (Sena et al., 2014).
Expression of soluble sCD163 in serum of psoriatic patients is modulated by Goeckerman therapy
2013, Allergologia et ImmunopathologiaCitation Excerpt :CD163 is the monocyte/macrophage receptor for haptoglobin–haemoglobin (Hp–Hb) complexes.6,7 It is a member of the scavenger receptor cysteine-rich (SRCR) superfamily8,9; specifically, it belongs to Group B superfamily.7,10,11 Many of the SRCR-proteins have been shown to be directly involved in the development of the immune system and in the regulation of the immune response.
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Sequence data from this article have been submitted to the EMBL/GenBank Data Libraries under Accession Nos. Y18388 to Y18403 (exons 1 to 16), AJ133107 (exon 17), and AJ224687 (5′-flanking region).
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Abbreviations used: DAPI, 4′,6-diamidino-2-phenylindole-dihydrochloride; FISH, fluorescence in situ hybridization; M-CSF, macrophage colony-stimulating factor; RACE, rapid amplification of cDNA ends; SRCR, scavenger receptor cysteine-rich; UTR, untranslated region
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To whom correspondence should be addressed at Institute for Clinical Chemistry and Laboratory Medicine, University of Regensburg, Franz-Josef-Strauß-Allee 11, D-93042 Regensburg, Germany. Fax: (49)-941-944-6202. E-mail: [email protected].