Biochemical and Biophysical Research Communications
Regular ArticleContortrostatin, a Homodimeric Disintegrin, Binds to Integrin αvβ5☆,☆☆
References (38)
- et al.
J. Biol. Chem.
(1991) - et al.
Exp. Cell Res.
(1988) Cell
(1992)- et al.
Cell
(1994) - et al.
J. Biol. Chem.
(1996) - et al.
Thromb. Res.
(1994) - et al.
J. Biol. Chem.
(1994) - et al.
Biochim. Biophys. Acta
(1997) - et al.
Blood
(1998) - et al.
J. Biol. Chem.
(1995)
Cell
Curr. Opin. Cell Biol.
Biochem. Biophys. Res. Commun.
Proc. Soc. Exp. Biol. Med.
Semin. Hematol.
J. Biol. Chem.
Science
J. Clin. Invest.
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Recent developments in animal venom peptide nanotherapeutics with improved selectivity for cancer cells
2021, Biotechnology AdvancesPreclinical studies of a novel snake venom-derived recombinant disintegrin with antitumor activity: A review
2020, Biochemical PharmacologyCitation Excerpt :Due to the limited amounts of disintegrins that are usually obtained from their natural snake venom source, functional expression of a recombinant version provided adequate material for further functional studies. Using native CN, it could be established that this disintegrin recognizes αIIbβ3, α5β1, αvβ3, and αvβ5 integrins [42,45,46]. The physiological binding partners for these integrins consist of fibrinogen, fibronectin, vitronectin, collagen, von Willebrand factor (vWF), thrombospondin 1 (TSP-1), and fibroblast growth factor 2 (FGF-2), and therefore blocking their activities by exposure to CN was expected to have a variety of complex effects [32].
The characterization of trans-pecos copperhead (Agkistrodon contortrix pictigaster) venom and isolation of two new dimeric disintegrins
2016, BiologicalsCitation Excerpt :For this reason, disintegrins could be investigated as therapeutic agents for many pathologies such as inflammation, autoimmune diseases, asthma, osteoporosis, thrombosis and cancer [10]. Two disintegrins (contortrostatin and acostatin) have been isolated from A. contortrix [28–30]. Contortrostin is a homodimer disintegrin whereas acostatin is a heterodimer disintegrin; both containing a RGD motif in each chain [29,30].
Anti-invasive and anti-adhesive activities of a recombinant disintegrin, r-viridistatin 2, derived from the Prairie rattlesnake (Crotalus viridis viridis)
2012, ToxiconCitation Excerpt :Integrins α6β1 and α6β4 are laminin-binding receptors that are involved in regulating tumor cell invasion (Rathinam and Alahari, 2010). In the specific condition of the invasion assay where the studies were performed in presence of a reconstituted basal membrane, r-viridistatin 2 could possibly inhibit the integrin αvβ3 present in SK-MEL-28 and T24, without excluding other possible integrins that might be targeted by r-viridistatin 2, such as αvβ5 integrin, which is highly expressed in MDA-MB-231 cells and has been reported to mediate cancer cell invasion (Taherian et al., 2011; Zhou et al., 2000; Wong et al., 1998). An important test to verify the effectiveness of the disintegrins as anti-cancer agents is the inhibition of lung tumor colonization in vivo.
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This research was supported by funds from the California Breast Cancer Research Program (CA-BCRP) of the University of California, Grants 1RB-0052 and 4CB-0083 (to F.S.M.).
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Abbreviations used: bFGF, basic fibroblast growth factor; BSA, bovine serum albumin; ECM, extracellular matrix; mAb, monoclonal antibody; PBS, phosphate-buffered saline; PKC, protein kinase C; R/KGD, Arg/Lys-Gly-Asp; VEGF, vascular endothelial growth factor
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Supported by a Postdoctoral Fellowship from CA-BCRP (3FB-0125), Postdoctoral Fellowship from the Susan G. Komen Breast Cancer Foundation (9860), and Cancer Center Core Grant Developmental Fund from USC/Norris Comprehensive Cancer Center (NCI Grant 5P30 CA 14089-24).
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To whom correspondence should be addressed at Cancer Research Laboratory, Room 106, University of Southern California, Keck School of Medicine, 1303 N. Mission Road, Los Angeles, CA 90033. Fax: 323-224-7679. E-mail: [email protected].