Biochemical and Biophysical Research Communications
Regular ArticleOverexpression of Vacuolar ATPase 16-kDa Subunit in 10T1/2 Fibroblasts Enhances Invasion with Concomitant Induction of Matrix Metalloproteinase-2☆
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2017, Seminars in Cancer BiologyCitation Excerpt :Only the knockdown of the a3 isoform lead to decreased cytosolic pH, whereas siRNAs to a3 and a4 significantly inhibited invasiveness in MDA-MB-231 cells [11]. Overexpression of the V-ATPase 16 kDa subunit enhanced invasiveness and matrix metalloproteinases, responsible for degrading extracellular matrix proteins, in mouse fibroblasts, whereas transfection of these mouse fibroblast with antisense oligonucleotides of the 16 kDa subunit of V-ATPase decreased both invasiveness and production of matrix metalloproteinases [23]. The ability to alter or disrupt the pH dynamics, alkaline pHi and acidic pHe, via MCTs, NHE1, or V-ATPase provides researchers and clinicians with the potential to reduce cancer growth, invasiveness and metastases, resistance to basic chemotherapeutics, and angiogenesis while increasing the rate of apoptosis.
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Abbreviations used: MMP, matrix metalloprotease; vacuolar-type H+-ATPase, V-ATPase.
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