Biochemical and Biophysical Research Communications
Regular ArticleEffects of cAMP on Intercellular Coupling and Osteoblast Differentiation
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Bone regenerative potential of the selective sphingosine 1-phosphate receptor modulator siponimod: In vitro characterisation using osteoblast and endothelial cells
2020, European Journal of PharmacologyCitation Excerpt :While some early studies have shown that parathyroid hormone stimulate the in vitro differentiation of osteoblasts via intracellular cAMP production (Nakatani et al., 1984), other reports show that the influence of cAMP on ALP expression changes depending on the stage of osteoblast differentiation, and parathyroid hormone may preferentially inhibit the differentiation of more mature osteoblasts (Isogai et al., 1996). Expanding on the complexity of the relation between cAMP and osteoblast differentiation markers, increasing levels of cAMP have been shown to result in decreased ALP but increased osteocalcin expression (Romanello et al., 2001). More recently, increasing cAMP levels have been shown to suppress osteoblast mineralisation (Nishihara et al., 2018).
Regulation of MC3T3-E1 differentiation by actin cytoskeleton through lipid mediators reflecting the cell differentiation stage
2019, Biochemical and Biophysical Research CommunicationsOsteochondromyxoma: Review of a rare carney complex criterion
2016, Journal of Bone OncologyRegulation of the connexin 43 promoter in the brook trout testis: Role of the thyroid hormones and cAMP
2011, General and Comparative EndocrinologyInteraction between human umbilical vein endothelial cells and human osteoprogenitors triggers pleiotropic effect that may support osteoblastic function
2008, BoneCitation Excerpt :This suggests at least that the channel function of these structures may not be responsible for the decrease of runx2 mRNA level. Previous works have shown that cAMP was able to inhibit ALP activity in osteoblastic cells [50]. ALP activity is stimulated by the co-culture whereas runx2 mRNA level is decreased in CoHOP.
Up-regulation of connexin 43 and gap junctional intercellular communication by Coleusin Factor is associated with growth inhibition in rat osteosarcoma UMR106 cells
2007, Cell Biology InternationalCitation Excerpt :The mechanism by which CF elicits Cx43 up-regulation requires further study. One of the possibilities is CF exerts this function through a cAMP pathway, as CF can result in cAMP accumulation in UMR106 cells immediately after the treatment (unpublished work), and increased levels of cAMP induced up-regulation of Cx43 and enhancement of GJ in osteoblast cells (Romanello et al., 2001). In the conventional creed, connexins only exert anti-tumour effects via forming GJ channels and restored GJIC (Holder et al., 1993).
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