Biochemical and Biophysical Research Communications
Regular ArticleTautomycetin Is a Novel and Specific Inhibitor of Serine/Threonine Protein Phosphatase Type 1, PP1
References (29)
Cell
(1995)Trends Biochem. Sci.
(1997)- et al.
Adv. Enzyme. Regul.
(1994) - et al.
Biochem. Biophys. Res. Commun.
(1993) Cell. Signal.
(2001)- et al.
J. Biol. Chem.
(1997) - et al.
Biochem. Biophys. Res. Commun.
(1989) - et al.
Toxicon
(1992) - et al.
Biochem. Pharmacol.
(1998) - et al.
J. Biol. Chem.
(1999)
FEBS Lett.
Bioorg. Med. Chem. Lett.
Anal. Biochem.
Methods Enzymol.
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2018, Developmental CellCitation Excerpt :In order to address the physiological importance of the delay in PNonset, we sought to accelerate PNonset. First, we tested phosphatase involvement in temporal regulation of PNonset by treatment with okadaic acid or tautomycetin, highly selective inhibitors of PP2A-B55 and PP1, respectively (Cohen et al., 1989; Mitsuhashi et al., 2001). The inhibitors were used at a concentration below the level that causes premature chromosome condensation (Dyban et al., 1993) (Figure S1A).
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