Biochemical and Biophysical Research Communications
Breakthroughs and ViewsWnt Signaling and Heterotrimeric G-Proteins: Strange Bedfellows or a Classic Romance?
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Developmental pathways in the pathogenesis of lung fibrosis
2019, Molecular Aspects of MedicineThe Wnts of change: How Wnts regulate phenotype switching in melanoma
2015, Biochimica et Biophysica Acta - Reviews on CancerCitation Excerpt :The Fzd receptors are seven-pass transmembrane G-protein coupled receptors, which upon Wnt binding, require heterotrimeric G-proteins for downstream signaling [29]. The activation of specific G-protein subunits depends on the Wnt ligand subtype and the Fzd receptor to which it binds [30,31]. Co-receptors also play an important role in Wnt signaling.
Frizzled receptors signal through G proteins
2013, Cellular SignallingWnt and Notch: Potent Regulators of Cardiomyocyte Specification, Proliferation, and Differentiation
2012, Muscle: Fundamental Biology and Mechanisms of DiseaseMultiple suppression pathways of canonical Wnt signalling control thymic epithelial senescence
2011, Mechanisms of Ageing and DevelopmentCitation Excerpt :Wnt-4, for example, has been described as activator of both β-catenin dependent canonical (Lyons et al., 2004) and JNK/PKC dependent non-canonical (Cai et al., 2002; Du et al., 1995) signalling pathways that interact at multiple levels. Apart from specific, there are also shared signalling elements in Wnt pathways including the main cell surface receptors Frizzleds (Fz) (Schulte and Bryja, 2007) as well as intracellular signalling molecules including G proteins (Malbon et al., 2001), Dishevelleds (Dvl) (Kuhl et al., 2001; Schulte and Bryja, 2007) and PKCs α (Kuhl et al., 2001), ζ (Ossipova et al., 2003), and δ (Kinoshita et al., 2003). PKCδ appears particularly important as this serine-threonin kinase can phosphorylate and therefore activate Dvls (Kinoshita et al., 2003) to relay ligand induced signals towards down-stream elements of Wnt cascades.
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