Regular ArticleMutations in the HFE Gene and Their Interaction with Exogenous Risk Factors in Hepatocellular Carcinoma☆,☆☆,★
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Cited by (36)
Does HFE Genotype Impact Macrophage Phenotype in Disease Process and Therapeutic Response?
2017, Biometals in Neurodegenerative Diseases: Mechanisms and TherapeuticsSingle nucleotide polymorphisms and risk of hepatocellular carcinoma in cirrhosis
2012, Journal of HepatologyCitation Excerpt :The risk of HCC in patients with genetic haemochromatosis is well established, particularly in patients with overt cirrhosis [70]. Several teams have reported that the prevalence of HFE C282Y mutations was increased in patients with HCC [71,72]. However, other studies have failed to confirm these associations [73–75].
Iron overload and HFE gene mutations in polish patients with liver cirrhosis
2011, Hepatobiliary and Pancreatic Diseases InternationalEASL clinical practice guidelines for HFE hemochromatosis
2010, Journal of HepatologyCitation Excerpt :Subgroup analysis for gender specific prevalence and different etiologies were statistically underpowered. However, three studies in HCC reported a frequency of C282Y-homozygotes of 5.5–10% [101,102,106] and three further studies found an increased prevalence of C282Y heterozygosity [103,105,107]. Only one study [104] did not find an association between HCC and the C282Y-polymorphism.
Hepatic iron overload and risk of hepatocellular carcinoma in cirrhosis
2010, Gastroenterologie Clinique et BiologiqueLiver cancer: Descriptive epidemiology and risk factors other than HBV and HCV infection
2009, Cancer LettersCitation Excerpt :HFE mutation seems to be associated with iron overload in patients with end-stage liver diseases and might accelerate hepatic fibrosis in patients with chronic hepatitis C infection [38]. However, results from small studies considering HFE mutations in HCC patients are conflicting, showing either no increased HCC risk [39] or a positive association of iron overload only in the presence of viral or alcohol induced liver damage or cirrhosis [40–42]. Hepatoblastoma is the most common childhood hepatic tumor [7].
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Grant support: Murst ex 40% 2000, Ricerca Finalizzata IRCCS 1998, Ricerca Finalizzata ISS 1999 (30/12/92 No. 502): “Storia naturale, terapia e prevenzione delle epatopatie acute e croniche.”
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Abbreviations used: HH, hereditary hemochromatosis; HCV, hepatitis C virus; HCC, hepatocellular carcinoma; HBV, hepatitis B virus; LIC, liver iron concentration; OR, odds ratio; CI, confidence intervals; RR, relative risk.
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Communicated by E. Beutler, M.D., 02/20/01
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Correspondence and reprint requests to: Silvia Fargion, Dipartimento di Medicina Interna, Università di Milano, Ospedale Maggiore IRCCS, Pad Granelli, Via F Sforza 35, Milan, Italy. Fax: 39-2-55180241. E-mail: [email protected].