Regular ArticleBromelain Treatment Alters Leukocyte Expression of Cell Surface Molecules Involved in Cellular Adhesion and Activation
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Enkephalin related peptides are released from jejunum wall by orally ingested bromelain
2019, PeptidesCitation Excerpt :Although we cannot discard the presence of serum stem bromelain concentrations lower than 30 ng/mL, due to limitation of the employed assay, an eventual undetectable level might not be adequate for the proteolysis of a significant amount of stem bromelain substrates after the blood access. In fact, stem bromelain concentrations greater than 500 μg/mL are required to surpass the alpha-2-macroglobulin inhibition in the blood [45]. Taken together, these data demonstrate that the anti-nociceptive effect of orally administered stem bromelain may likely reflect its local proteolytic activity within the jejunum tract, rather than a systemic response.
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