A New Murine Model for Mammalian Wound Repair and Regeneration

doi:10.1006/clin.1998.4519

Clinical Immunology and Immunopathology

Volume 88, Issue 1, July 1998, Pages 35-45

Clinical Immunology ...

https://doi.org/10.1006/clin.1998.4519 Get rights and content

Abstract

Regeneration is generally considered to be a phenomenon restricted to amphibians in which amputated limbs reform and regrow. We have recently noted a strain of mouse, the MRL, which displays a remarkable capacity for cartilagenous wound closure and provides an example of a phenomenon previously considered to be a form of regeneration. Specifically, through-and-through ear punches rapidly attain full closure with normal tissue architecture reminiscent of regeneration seen in amphibians as opposed to scarring, as usually seen in mammals. Histologically, we have demonstrated normal cell growth and microanatomy, including angiogenesis and chondrogenesis, as opposed to control C57BL/6 mice which have ear holes that contract minimally but do not close. Finally, this phenomenon is a genetically definable quantitative trait.

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^☆: D. ZakimT. D. Boyer

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Regular ArticleA New Murine Model for Mammalian Wound Repair and Regeneration☆

Abstract

Dev. Biol.

Clin. Immunol. Immunopathol.

Differentiation

Getting to mammalian wound repair and amphibian limb regeneration: A mechanistic link in the early events

Wound Repair Regen.

Tissue restoration: Approaches and prospects

Wound Repair Regen.

Mice regrow the tips of the foretoes

Science

Problems of antlerogenesis

Clin. Orthop.

Epidermal downgrowths in regenerating rabbit ear holes

J. Morphol.

Hepatic regeneration

Hepatology: A Textbook in Liver Disease

Liver regeneration

Science

Angiogenic factors

Science

Epithelial stem cells in vivo

Wound healing—Aiming for perfect skin regeneration

Science

Purification and characterization of mouse hematopoietic stem cells

Science

Bone and cartilaginous tissue

Autoimmunity and lymphoproliferation: Induction by mutant gene lpr and acceleration by a male-associated factor in strain BXSB

Lpr and gld: Single gene models of systemic autoimmunity and lymphoproliferartive disease

Annu. Rev. Immunol.

Regular Article
A New Murine Model for Mammalian Wound Repair and Regeneration☆