Regular articleMIGRATION RESPONSES OF HUMAN MONOCYTIC CELL LINES TO α- AND β-CHEMOKINES
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Rac1 plays a role in CXCL12 but not CCL3-induced chemotaxis and Rac1 GEF inhibitor NSC23766 has off target effects on CXCR4
2018, Cellular SignallingCitation Excerpt :Specifically, Cdc42 and Rac1 regulate filopodia and lamellopodia formation, respectively, while RhoA regulates stress fibres and focal adhesion [19]. It has been well documented that activation of chemokine receptors leads to the occurrence of actin stress fibres and membrane ruffling [20–22]. It has also been shown that the blocking of RhoA or ROCK (rho-activated kinase) prevents migration of cells [16].
S1P-Dependent Trafficking of Intracellular Yersinia pestis through Lymph nodes establishes buboes and systemic infection
2014, ImmunityCitation Excerpt :By real-time PCR, we determined substantial increases in the expression of chemokines, including CCL2, CCL3, CCL4, and CXCL10 (also known as MCP-1, MIP-1α, MIP-1β, and IP-10, respectively) within dLNs with Y. pestis infection, compared to saline controls (Figures 2F and S6). Each of these chemokines has a well-established role in the recruitment of monocytes, DCs, and/or macrophages (Cross et al., 1997; Shi and Pamer, 2011). In order to compare Y. pestis-induced chemokine increases within the context of other infections, we also examined the chemokine production in LNs to two other Gram-negative pathogens, Escherichia coli (where infection remains confined to the site of infection) and Salmonella Typhimurium (which has well-established dLN-targeting adaptations) (St John and Abraham, 2009).
Human and murine model cell lines for dendritic cell biology evaluated
2008, Immunology LettersCitation Excerpt :Moreover, THP-1 show directed migration towards several chemokines important for DC migration, while HL-60 cells can only do so when differentiated towards monocytes [70]. In contrast to primary DCs, however, neither of these two cell-types switch to a high-speed migration mode in response to maturation [71]. Relative to primary DCs, MUTZ-DCs are poorly adhesive, even in the immature state, but similar to DCs, MUTZ-DCs acquire a more migratory phenotype in response to maturation (our own observations).
Modulation of the chemokines KC and MCP-1 by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in mice
2007, Archives of Biochemistry and BiophysicsThe IL sequence in the LLKIL motif in CXCR2 is required for full ligand-induced activation of Erk, Akt, and chemotaxis in HL60 cells
2006, Journal of Biological ChemistryIntestinal neuro-epithelial interactions modulate neuronal chemokines production
2006, Biochemical and Biophysical Research Communications
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Correspondence to: R. C. Rees, Department of Life Sciences, Nottingham Trent University, Clifton Lane, Notingham NG11 8NS, UK