Elsevier

Cytokine

Volume 14, Issue 6, June 2001, Pages 357-360
Cytokine

Short Communications
CYTOKINES IN CERVICOVAGINAL WASHING FLUID FROM PATIENTS WITH CERVICAL NEOPLASIA

https://doi.org/10.1006/cyto.2001.0909Get rights and content

Abstract

Human papillomavirus (HPV) infections play an important role in the development of cervical neoplasia. To get to a better understanding of the role of cytokines in the development of these neoplasias, we analysed the presence of various cytokines in cervicovaginal washings of healthy volunteers (n=22), cervical intraepithelial neoplasia (CIN) patients (n=63) and cervical cancer patients (n=33). IL-12p40, IL-10, TGF-β1, TNF-α and IL-1β levels were significantly higher in patients with cervical cancer than in controls and CIN patients. The levels of IFN-γ were not different. Our data demonstrate alterations in the local cervical immune environment in cervical cancer patients. This could have important consequences for the further development of immune modulating therapies and vaccination strategies.

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Correspondence to: T. A. Out, Ph.D., Academic Medical Center, B1-236, P.O. Box 22700, 1100 DE Amsterdam, The Netherlands. E-mail:[email protected]

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