Elsevier

Cytokine

Volume 20, Issue 4, November 2002, Pages 184-190
Cytokine

Regular Articles
PROGNOSTIC ROLE OF SERUM VASCULAR ENDOTHELIAL GROWTH FACTOR, BASIC FIBROBLAST GROWTH FACTOR AND NITRIC OXIDE IN PATIENTS WITH COLORECTAL CARCINOMA

https://doi.org/10.1006/cyto.2002.1993Get rights and content

Abstract

Recently, angiogenesis has gained an increasing interest as a prognostic factor in a variety of solid tumours. In this study we aimed to assess the prognostic role of serum vascular endothelial growth factor (VEGF), basic fibroblast growth factor (b-FGF) and nitric oxide (NO) levels in patients with colorectal carcinoma (CRC).

A total of 52 consecutive colorectal cancer patients with stage I to IV disease was included. In addition to routine laboratory and staging procedures, serum VEGF, b-FGF levels, and nitrate levels as a surrogate marker for in-vivo NO production were assayed.

Serum VEGF concentrations, adjusted to the platelet count were found to be a significant factor for overall survival in univariate analysis (P=0.033). A new angiogenic index (AI), derived from serum VEGF and nitrate concentrations, was established. AI is the only independent prognostic factor of survival in all patients (P=0.008, Cox regression analysis). Likewise, AI is also significant prognostic factor for disease-free survival (DFS) in patients with operable CRC (P=0.032, Cox regression analysis).

In conclusion, serum VEGF and NO levels have prognostic role in patients with CRC and the new angiogenesis index using the serum levels of the factors seem to be useful.

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    Correspondence to: Dr Hakan Akbulut, Department of Medical Oncology, Ibni Sina Hospital, Ankara University Faculty of Medicine, Sihhiye, Ankara 06100, Turkey. Tel: +90 312 3103333; Fax: +90 312 3121650; E-mail:[email protected]

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