ReviewSignaling by wingless in Drosophila
References (0)
Cited by (190)
The logistics of Wnt production and delivery
2023, Current Topics in Developmental BiologyA single ortholog of teashirt and tiptop regulates larval pigmentation and adult appendage patterning in Bombyx mori
2020, Insect Biochemistry and Molecular BiologyCitation Excerpt :Loss-of-function alleles of wg result in embryonic lethality (Nüsslein-Volhard and Wieschaus, 1980). wg is an important member of the wnt family, encoding a secreted protein that is essential for the development of wings in D. melanogaster (Klingensmith and Nusse, 1994). In wing imaginal disc cells, wg appears on the apical surface and is then transported to the basolateral surface, eventually triggering the signal (Yamazaki et al., 2016).
Wnt gene regulation and function during maxillary palp development in Drosophila melanogaster
2020, Developmental BiologyCitation Excerpt :Many of the key insights into the functions of Wnt ligands have come from studies in Drosophila melanogaster, which has retained seven Wnt ligand genes: Wnt1 (wingless (wg)), Wnt5 (Dwnt3), Wnt6, Wnt7 (Dwnt2), Wnt8 (WntD), Wnt9 (Dwnt4) and Wnt10 (Llimargas and Lawrence, 2001; Murat et al., 2010). In Drosophila, wg is crucial for many different aspects of development from segmentation to growth, patterning and differentiation of the imaginal discs (Bejsovec, 2018; Klingensmith and Nusse, 1994; Swarup and Verheyen, 2012; Wodarz and Nusse, 1998). In contrast, the other six Drosophila Wnt genes appear to play more restricted roles during development and the functions of some ligands, for example Wnt6 and Wnt10, are still not completely clear or unknown respectively (Murat et al., 2010).
Integrated analysis of miRNA and mRNA expression profiles in 2-, 6-, and 12-month-old Small Tail Han Sheep ovaries reveals that oar-miR-432 downregulates RPS6KA1 expression
2019, GeneCitation Excerpt :It has been reported that miR-432 is involved in cell differentiation and proliferation (Ren et al., 2016), and plays an important role as a tumor suppressor gene in ovarian cancer and cervical cancer (Kim et al., 2014; Yao et al., 2013). miR-432 also participates in the WNT/β-catenin signaling pathway, which plays important roles in both embryonic development and tumorigenesis (Klingensmith and Nusse, 1994; Gumbiner, 1995). miR-432 has been widely studied in human cancers, but its role in reproductive organ development has not been reported.
From Research to the Clinic: Targeting Stem Cell Pathways in Cancer
2016, Cancer Stem Cells: Targeting the Roots of Cancer, Seeds of Metastasis, and Sources of Therapy ResistanceThe role of Bro1- domain-containing protein Myopic in endosomal trafficking of Wnt/Wingless
2014, Developmental BiologyCitation Excerpt :In metazoans, Wnt signaling [Wingless (Wg) in Drosophila] is one of these evolutionarily conserved signaling networks that regulate cell-fate specification, tissue differentiation, and stem-cell development (Clevers and Nusse, 2012). Aberrant Wnt signaling is implicated in a variety of developmental disorders and cancers (Klingensmith and Nusse, 1994). Wg, the Drosophila homolog of Wnt1, is a secreted glycoprotein (Clevers and Nusse, 2012) that upon secretion acts on its neighbouring signal-receiving cells to activate the pathway (Neumann and Cohen, 1996; Zecca et al., 1996) .