Regular ArticlePrenatal Exposure to Methylmercury during Late Gestation Affects Cerebral Opiatergic System in Rat Offspring☆
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Cited by (9)
Environmental toxic agents: The impact of heavy metals and organochlorides on brain development
2020, Handbook of Clinical NeurologyCitation Excerpt :Other findings show that low-level Pb exposure during development created regional increased levels of serotonin and catecholaminergic neurotransmission in the cerebral cortex, hippocampus, and cerebellum (Leret et al., 2002; Devi et al., 2005), and it is associated with decreased levels of glutamate and gamma-aminobutyric acid (GABA) (Leret et al., 2002). Experimental studies have also associated MeHg exposure with the disruption of adrenergic (Lindström et al., 1991), cholinergic (Coccini et al., 2000), GABAergic (Guidetti et al., 1992; Yuan and Atchison, 2003), and opiatergic systems (Zanoli et al., 1997). Likewise, PCB exposure has been identified as a disruptor of neurotransmitters such as serotonin (Seegal et al., 1986), noradrenaline (Seegal et al., 1985), and dopamine (Cory-Slechta et al., 1997).
Neonatal administration of a vaccine preservative, thimerosal, produces lasting impairment of nociception and apparent activation of opioid system in rats
2009, Brain ResearchCitation Excerpt :While there are no published data on opioid peptides and THIM or ethylmercury, methylmercury has been shown to increase release of peptides linked to pain control at spinal and supraspinal regions of the CNS (Baxter and Smith, 1998; Ortega et al., 1997). Moreover, in developmental studies, delayed upregulation of μ and δ opioid receptors in brains of rats exposed to methylmercury in utero was described (Zanoli et al., 1997). Using immunohistochemical assay we also found several-fold increase of density of μ receptors in the periaqueductal gray region of neonatally THIM exposed rats (manuscript in preparation).
Prenatal exposure to methyl mercury in rats: Focus on changes in kynurenine pathway
2001, Brain Research BulletinPrenatal morphine exposure differentially alters learning and memory in male and female rats
2001, Physiology and BehaviorNeurotransmitter levels in two populations of larval Fundulus heteroclitus after methylmercury exposure
1999, Comparative Biochemistry and Physiology - C Pharmacology Toxicology and EndocrinologyBehavioural effects of exposure to methylmercury during early development
2012, Methylmercury and Neurotoxicity
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R. SchwarczYehezkel-Ari, Eds.