Regular ArticleCollagen VI Regulates Normal and Transformed Mesenchymal Cell Proliferationin Vitro
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Harnessing the synergy of perfusable muscle flap matrix and adipose-derived stem cells for prevascularization and macrophage polarization to reconstruct volumetric muscle loss
2023, Bioactive MaterialsCitation Excerpt :In particular, collagen V has been found to augment tissue generation and organoid formation [35], and collagen XIA1 helps maintain the spacing and width of the network-forming collagens VIA1, VIA2, and VIA3. Collagen VI, which is primarily associated with the skeletal muscle ECM, maintains regularity in muscle function and stabilizes the cell membrane [36]; it has also been shown to benefit mesenchymal cell growth and inhibit apoptosis [37]. These special functions make collagen VI an important component of any bioscaffold used for muscle tissue engineering and reconstruction.
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