Regular ArticleInvolvement of Ets Transcription Factors and Targets in Osteoblast Differentiation and Matrix Mineralization
References (57)
- et al.
Gene regulation by Ets proteins
Biochim. Biophys. Acta
(1993) - et al.
Signal transduction within the nucleus by mitogen-activated protein kinase
J. Biol. Chem.
(1992) - et al.
Synergistic transcriptional activation of the tissue inhibitor of metalloproteinases-1 promoter via functional interaction of AP-1 and Ets-1 transcription factors
J. Biol. Chem.
(1996) - et al.
Effects of sphingosine derivatives on MC3T3-E1 pre-osteoblasts: Psychosine elicits release of calcium from intracellular stores
Biochem. Biophys. Res. Commun.
(1995) - et al.
Interaction of human T-cell lymphotropic virus type I Tax, Ets1, and Sp1 in transactivation of the PTHrP P2 promoter
J. Biol. Chem.
(1997) - et al.
Osf2/Cbfa1: A transcriptional activator of osteoblast differentiation [see comments]
Cell
(1997) - et al.
Identification of novel genes from stomach cancer cell lines by differential display
Cancer Lett.
(1995) - et al.
The ets gene family
Cell Growth Differ.
(1992) - et al.
Differential expression of ets-1 and ets-2 proto-oncogenes during murine embryogenesis
Oncogene
(1994) - et al.
The Ets1 transcription factor is widely expressed during murine embryo development and is associated with mesodermal cells involved in morphogenetic processes such as organ formation
Proc. Natl. Acad. Sci. USA
(1993)
Defective activation and survival of T cells lacking the Ets-1 transcription factor
Nature
Mammalian ets-1 and ets-2 genes encode highly conserved proteins
Proc. Natl. Acad. Sci. USA
The Ets family of transcription factors
Eur. J. Biochem.
Characterization of SAP-1, a protein recruited by serum response factor to the c-fos serum response element
Cell
c-ets1 proto-oncogene is a transcription factor expressed in endothelial cells during tumor vascularization and other forms of angiogenesis in humans
Am. J. Pathol.
Differential regulation of interstitial collagenase (MMP-1) gene expression by ETS transcription factors
Oncogene
Effects of 1,25-dihydroxyvitamin D3 on osteoblastic MC3T3-E1 cells
Endocrinology
Down's syndrome-like skeletal abnormalities in Ets2 transgenic mice
Nature
Cell population kinetics of an osteogenic tissue
J. Cell Biol.
Progressive development of the rat osteoblast phenotype in vitro: Reciprocal relationships in expression of genes associated with osteoblast proliferation and differentiation during formation of the bone extracellular matrix
J. Cell. Physiol.
Skeletal system and ossification
Developmental expression of 2ar (osteopontin) and SPARC (osteonectin) RNA as revealed by in situ hybridization
J. Cell Biol.
Gene expression during endochondral bone development: Evidence for coordinate expression of transforming growth factor beta 1 and collagen type I
J. Cell Biochem.
Factors that promote progressive development of the osteoblast phenotype in cultured fetal rat calvaria cells
J. Cell. Physiol.
Accumulation, localization, and compartmentation of transforming growth factor beta during endochondral bone development
J. Cell Biol.
Skeletal tissue and transforming growth factor beta
FASEB J.
Mechanism of calcification: Role of collagen fibrils and collagen-phosphoprotein complexes in vitro and in vivo
Anat. Rec.
Developmental expression of tissue inhibitor of metalloproteinase (TIMP) RNA
Development
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The roles of non-coding RNAs in vascular calcification and opportunities as therapeutic targets
2021, Pharmacology and TherapeuticsCitation Excerpt :Other research found V-ets erythroblastosis virus E26 oncogene homolog 1 (Ets1) as a miR-125b target (Wen et al., 2014). Ets transcriptional factors are reported to be involved in osteoblast proliferation, differentiation, and mineralization (Vary et al., 2000). Overexpressing miR-125b was shown to suppress osteogenic markers, mineralization, and Ets1 protein expression in β-glycerophosphate-induced rat VSMC, whereas inhibiting miR-125b showed the opposite results (Wen et al., 2014).
miR-532-3p inhibits osteogenic differentiation in MC3T3-E1 cells by downregulating ETS1
2020, Biochemical and Biophysical Research CommunicationsRegulation of the 5′-flanking region of the human CYP27B1 gene in osteoblast cells
2009, Molecular and Cellular EndocrinologyEffect of different biomaterials on the expression pattern of the transcription factor Ets2 in bone-like constructs
2009, Journal of Cranio-Maxillofacial SurgeryCitation Excerpt :Nevertheless it is important to investigate changes in gene expression which occur in the ex vivo expansion of osteoblasts during tissue engineering. Transcription factors, like V-ets erythroblastosis virus E26 oncogene homolog 2 (avian) (Ets2), have been shown to act as master regulators of development and physiological bone metabolic processes (Vary et al., 2000), but they have also been reported to play important roles as mediators of cellular transformation and tumour formation (Bartel et al., 2000; Arnold et al., 2002). Ets2 is a prototypical member of the Ets-family of transcription factors, which comprises at least 30 unique members, all containing an evolutionary conserved DNA binding domain (EtsDBD) (Sharrocks, 2001; Oikawa and Yamada, 2003; Hsu et al., 2004).
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