Regular ArticleSensitivity of the Origin Decision Point to Specific Inhibitors of Cellular Signaling and Metabolism
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Development of quantitative and high-throughput assays of polyomavirus and papillomavirus DNA replication
2010, VirologyCitation Excerpt :We found that both compounds could prevent viral DNA replication (geldanamycin: IC50 = 0.025 and 0.05 μM for SV40 and HPV; 17-AAG: IC50 = 0.5 μM for both SV40 and HPV), with less of an effect on expression of CMV-Fluc. Finally, we investigated the effect of the proteasome inhibitor lactacystin, which was also reported to block S-phase entry by arresting cells either in G1 or G2/M phase (Katagiri et al., 1995; Keezer and Gilbert, 2002). Like the two HSP90 inhibitors, lactacystin inhibited viral DNA replication (IC50 = 1.25 μM for both SV40 and HPV).
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