Regular articleVariability in Rate of Cone Degeneration in the Retinal Degeneration (rd/rd) Mouse☆
References (28)
- Bowes, C. Li, T. Danciger, M. Baxter, L. C. Applebury, M. L. Farber, D. B. 1990, Retinal degeneration in therd, Nature,...
- Calderone, J. B. Jacobs, G. H. 1995, Regional variations in the relative sensitivity to UV light in the mouse retina....
- Carter-Dawson, L. D. LaVail, M. M. 1979, Rods and cones in the mouse retina. I. Structural analysis using light and...
- Carter-Dawson, L. D. LaVail, M. M. Sidman, R. L. 1978, Differential effect of therd, Invest. Ophthalmol. Vis. Sci. 17,...
- Cohen, A. I. McDaniel, M. Orr, H. 1973, Absolute levels of some free amino acids in normal and biologically...
- Dräger, U. C. Hubel, D. H. 1978, Studies of visual function and its decay in mice with hereditary retinal degeneration....
- Faktorovich, E. G. Steinberg, R. H. Yasumura, D. Matthes, M. T. LaVail, M. M. 1990, Photoreceptor degeneration in...
- Faktorovich, E. G. Steinberg, R. H. Yasumura, D. Matthes, M. T. LaVail, M. M. 1992, Basic fibroblast growth factor and...
- Farber, D. B. Flannery, J. G. Bowes-Rickman, C. 1994, Therd, Progress in retinal and eye research, Vol. 13, No. 1. 31,...
- Gal, A. Orth, U. Baehr, W. Schwinger, E. Rosenberg, T. 1994, Heterozygous missense mutation in the rod cGMP...
Cited by (83)
Cellular mechanisms of hereditary photoreceptor degeneration – Focus on cGMP
2020, Progress in Retinal and Eye ResearchCitation Excerpt :The rd1 mouse is characterized by a mutation in the gene encoding for the β subunit of rod PDE6 (Bowes et al., 1990), a lack of PDE6 protein (Yan et al., 1998) and exceedingly high levels of cGMP in rods (Farber and Lolley, 1974; Paquet-Durand et al., 2009). This leads to rapid loss of most of the rods within the first two weeks after birth (Sahaboglu et al., 2013), followed by a mutation-independent, secondary death of cones (LaVail et al., 1997). Another mouse model with a mutation (albeit different from that of rd1) in the Pde6b gene is the rd10 mouse (Chang et al., 2002).
The mechanism of cone cell death in Retinitis Pigmentosa
2018, Progress in Retinal and Eye ResearchCitation Excerpt :To do this, retinal flat mounts were stained with FITC-labeled peanut agglutinin (FITC-PNA), which stains cone matrix sheaths, and image analysis was used to determine the number of cones in the same 230 × 230 μm regions 1 mm superior, inferior, temporal, and nasal to the optic nerve. It is critical that cone cell density be determined in corresponding squares of retina in each mouse because the rate of cone cell death is not uniform across the retina (LaVail et al., 1997). Using this technique, it was found that at P21 when the majority of rods have died, cone density was not significantly different from that in wild type mouse retinas, but by P35 it was reduced by 80% (Komeima et al., 2006), which is consistent with previous reports (Carter-Dawson et al., 1978).
Molecular and Biochemical Aspects of the Retina on Refraction
2015, Progress in Molecular Biology and Translational ScienceSingle-Cell Transcriptomic Profiling in Inherited Retinal Degeneration Reveals Distinct Metabolic Pathways in Rod and Cone Photoreceptors
2022, International Journal of Molecular Sciences
- ☆
Osborne, N.Chader, G.) .
- f1
For correspondence and reprint requests: Matthew M. LaVail, Beckman Vision Center, University of California, San Francisco, San Francisco, CA 94143-0730, U.S.A.