Regular ArticleEarly Amyloid Deposition in the Medial Temporal Lobe of Young Down Syndrome Patients: A Regional Quantitative Analysis☆
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2021, The Lancet NeurologyCitation Excerpt :Intracellular amyloid-β within endosomes can promote mitochondrial dysfunction and oxidative damage.20 In people with Down syndrome aged 20–30 years, amyloid-β deposits appear as diffuse plaques (although plaques at younger ages have been noted), followed by neuritic plaques in the fourth decade of life.21,22 Neurofibrillary tangles appear after the initial deposition of amyloid-β in a pattern consistent with Braak staging (figure 1).15
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G. Paxinos
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