Regular ArticleRole of TNF-α Receptors in Mice Intoxicated with the Parkinsonian Toxin MPTP
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2015, NeuroscienceCitation Excerpt :TNFR-mediated neuroprotection is not limited to conditions of acute ischemic injury. In a mouse model for PD, induced by peripheral injection of mitochondrial complex 1 inhibitor 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), mice deficient in both TNFR, but not individual receptors, showed reduced dopamine levels before and after acute MPTP intoxication compared to controls although numbers of nigral dopaminergic neurons were not altered (Rousselet et al., 2002). In another study, acute MPTP intoxication increased neuronal damage in the hippocampus of double TNFR-deficient mice, pointing to a combined neuroprotective effect of the two TNFR (Sriram et al., 2006).
MPTP activates ASK1-p38 MAPK signaling pathway through TNF-dependent Trx1 oxidation in parkinsonism mouse model
2015, Free Radical Biology and MedicineMethods and Models of the Nonmotor Symptoms of Parkinson Disease
2015, Movement Disorders: Genetics and Models: Second EditionThe effect of dopamine on MPTP-induced rotarod disability
2013, Neuroscience LettersCitation Excerpt :Some reports have shown rotarod disability 3 days after MPTP administration [25], while others show no difference [23]. Similarly, conflicting reports are observed at 7 days post-lesion [1,17,20]. Impairment is consistently observed 40 days or more post-lesion [11,21].