Regular ArticleNew Evidence for Estrogen Receptors in Gonadotropin-Releasing Hormone Neurons☆
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Estrogens and the circadian system
2022, Seminars in Cell and Developmental BiologyCitation Excerpt :Estrogen-induced LH surges and c-Fos expression in GnRH neurons were absent in ERα KO female mice and restored in ovariectomized mice treated with ERα agonist [87–89]. GnRH neurons in mice and rats do not express ERα, so estrogen-ERα regulation of GnRH cells must be indirect [90,91]. In sum, there is a daily rhythm of estrogen feedback, via ERα, on GnRH neuron activation that promotes the GnRH surge on the afternoon of proestrus when estrogen levels are elevated.
Kobayashi Award 2019: The neuroendocrine regulation of the mammalian reproduction
2022, General and Comparative EndocrinologyCitation Excerpt :Among estrogen receptors (ERs), ERα has been known to mediate estrogen negative and positive feedback on GnRH/gonadotropin release, because ERα KO mice failed to show both types of feedback (Couse and Korach, 1999; Rosenfeld et al., 2000). On the other hand, target neuron(s) of estrogen had been a mystery until the discovery of the kisspeptin neuron as a potent mediator for the feedback, because no report had shown that GnRH neurons express ERα mRNA and its protein (Herbison and Pape, 2001). The missing piece to this puzzle must be ERα-expressing upper regulator(s) for GnRH release.
Diverse role of endocannabinoid system in mammalian male reproduction
2021, Life Sciences
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Address correspondence and reprint requests to Allan E. Herbison, Laboratory of Neuroendocrinology, The Babraham Institute, Cambridge CB2 4AT, UK. Fax: 44-1223-496 022. E-mail: [email protected].