Elsevier

Genomics

Volume 17, Issue 1, July 1993, Pages 256-259
Genomics

Short Communication
D21S418E Identifies a cAMP-Regulated Gene Located on Chromosome 21q22.3 That Is Expressed in Placental Syncytiotrophoblast and Choriocarcinoma Cells

https://doi.org/10.1006/geno.1993.1317Get rights and content
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Abstract

A partial cDNA (D21S418E) whose nucleotide sequence has no significant homologies with known mammalian DNA sequences was isolated from a human placental library. The cDNA hybridized with a 10-kb transcript present in term placenta. Messages of 10 and 7.5 kb were induced in BeWo and JEG-3 choriocarcinoma cells by treatment with 8-Br-cAMP. The mRNA was not detected in human brain, liver, lung, kidney, pancreas, heart, skeletal muscle, or myometrium. The D21S418E locus was assigned to a 3.5-Mb region of chromosome 21q22.3.

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