Regular ArticleStructure of the Human Type-I Interferon Gene Cluster Determined from a YAC Clone Contig
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Comprehensive network map of transcriptional activation of chicken type I IFNs and IFN-stimulated genes
2020, Comparative Immunology, Microbiology and Infectious DiseasesCitation Excerpt :Unlike other mammalian and chicken IFNs, chIFN-κ gene locus was located outside the mammalian and chicken type I IFNs locus [6,24,25]. Evolutionary analysis of respective IFN-κ genes was also investigated and no ortholog of chIFN-κ was found in other species suggesting us a separate different path of evolution for IFN-κ from other IFNs [24,26]. When compared to other species, chIFN-κ gene was found to possess 37 % homology with human IFN-κ [24], while 35 % and 27 % homology to bat [27] and mouse IFN-κ [25], respectively.
PROPERTIES AND FUNCTIONS OF THE NOVEL TYPE I INTERFERON EPSILON
2019, Seminars in ImmunologyCitation Excerpt :This early work also demonstrated that Ifnε maps to a human orthologue on the extreme centromeric end of 9p21 where it shares a relative position within the type I IFN locus (Fig. 1). The human locus, comprising 17 known genes and 12 pseudogenes distributed over approximately 400kb[19,29–31] includes IFNε, which encodes an open reading frame of 208 amino acids from which cDNA was first amplified in human WISH cells[19]. The discovery of IFNε, expanded an already extensive family of related genes in both humans and mice: there are now 13 designated IFNαs, as well as solitary IFNβ and IFNε genes.