Elsevier

Genomics

Volume 32, Issue 2, 1 March 1996, Pages 285-288
Genomics

Short Communication
Mapping of the Genes Encoding Mouse Prostaglandin D, E, and F and Prostacyclin Receptors

https://doi.org/10.1006/geno.1996.0118Get rights and content

Abstract

Prostaglandins and prostacyclin are metabolites of arachidonic acid and exert a variety of actions to maintain local homeostasis in the body. Their actions are mediated by cell surface receptors specific to the respective ligands. Using a panel of interspecific backcross mice, we have mapped the prostaglandin D receptor gene (Ptgdr), prostaglandin E receptor subtype EP1gene (Ptgerep1), prostaglandin F receptor gene (Ptgfr), and prostacyclin receptor gene (Ptgir).Ptgdrmapped to proximal Chr 14,Ptgfrmapped to distal Chr 3,Ptgerep1mapped to middle Chr 8, andPtgirmapped to proximal Chr 7.

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Cited by (16)

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    Chromosomal localization of the mouse and human prostanoid receptors genes has been reported. The genes encoding the mouse DP, EP1, EP3, EP4, FP, IP, and TP receptors were mapped to chromosomes 14, 8, 3, 15, 3, 7, and 10, respectively [75,76]. The genes encoding the human EP1, EP3, EP4, FP, IP, and TP receptors were mapped to chromosome bands 19p13.1, 1p31.2, 5p13.1, 1p31.1, 19q13.3, and 19p13.3, respectively [77,78].

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    Although the predicted amino acid sequence of the FP receptor exhibits the greatest sequence homology to EP1 and TP receptors, it is also quite similar to the EP3 receptor (48, 49). It is notable that the FP and EP3 receptors are syntenic, residing in close proximity on chromosome 1 in humans (50) and chromosome 3 in mice (51). In addition, multiple C-terminal splice variants exist for both FP and EP3 receptors (52-55).

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