Regular ArticleSequence Analysis in the Olfactory Receptor Gene Cluster on Human Chromosome 17: Recombinatorial Events Affecting Receptor Diversity☆
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The human olfactory receptor 17-40: Requisites for fitting into the binding pocket
2011, Computational Biology and ChemistryCitation Excerpt :Results reported by Singer (2000) for OR-I7 and Hatt et al. (1999) for OR 17-40 were successfully reproduced by Levasseur et al. (2003), who expressed both rat OR-I7 and human OR 17-40 in mammalian cells to investigate their ligand-binding specificities. The cells expressing recombinant OR-I7 exclusively responded to aldehydes, namely heptanal, octanal and nonanal, in line with previous reports (Araneda et al., 2000; Glusman et al., 1996), where octanal was the main ligand for the rat OR-I7. These results and those of Levasseur et al. (2003) are in fact complementary.
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Sequence data from this article have been deposited with the EMBL/GenBank Data Libraries under Accession No. U58675.
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