Short CommunicationCloning of Human Lymphocyte-Specific Interferon Regulatory Factor (hLSIRF/hIRF4) and Mapping of the Gene to 6p23–p25☆
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Prognostic significance of interferon regulating factor 4 in esophageal squamous cell carcinoma
2018, Biochemical and Biophysical Research CommunicationsCitation Excerpt :IRF4 is constitutively expressed in B-cells, and supports B-cell development. In particular, the highest level of IRF4 is observed in plasma cells [28]. In order to further understand the role of tumor-infiltrating B-cells, and the involvement of the humoral immune cells in anti-tumor immunity in ESCC, we sought in this project to examine the prognostic impact of the transcription factor IRF4 in ESCC.
Value of melanocytic-associated immunohistochemical markers in the diagnosis of malignant melanoma: A review and update
2014, Human PathologyCitation Excerpt :The MUM1 protein comprises 451 amino acids, has a molecular weight of ~52 kd, and is encoded by a gene located on chromosome 6p25.3. In normal tissues, MUM1 is found to be expressed only in lymphoid cells including plasma cells, a subset of germinal center B cells, and activated T cells and in melanocytes [147-149]. Among tumors, MUM1 expression has been reported in a wide spectrum of hematolymphoid neoplasms and melanocytic tumors [149].
XA polymorphism in IRF4 affects human pigmentation through a tyrosinase-dependent MITF/TFAP2A pathway
2013, CellCitation Excerpt :A few reports have linked IRF4 to pigment cells. IRF4 is expressed in melanocytes in the skin and in the G361 melanoma cell line (Grossman et al., 1996) as well as in most melanomas (Sundram et al., 2003). Importantly, IRF4 is associated with human pigmentation (Sulem et al., 2007; Han et al., 2008), and IRF4 expression correlates with MITF expression in melanoma cells (Hoek et al., 2008).
Colorful DNA polymorphisms in humans
2013, Seminars in Cell and Developmental BiologyCitation Excerpt :The derived 374F allele is almost fixed in people of European descent, highly frequent in Uygurs from Urumqi (west China), and quite rare in the other populations examined [141,144]. IRF4 (6p25-p23) encodes the interferon regulatory factor 4, detected in malignant melanoma and normal melanocytes [145], is lymphocyte specific in expression and negatively regulates Toll-like-receptor signaling that is central to the activation of innate and adaptive immune systems [146]. An intergenic SNP close to IRF4 was initially found to be associated with freckling in a GWAS on human pigmentation [17].
Immunohistology of Non-Hodgkin Lymphoma
2011, Diagnostic Immunohistochemistry
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Sequence data from this article have been deposited with EMBL/GenBank Data Libraries under Accession Nos. U52682 and U52683 for the cDNA and promoter sequence, respectively. The gene symbol IRF4 has been adopted for this locus.
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These authors contributed equally to this work.
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To whom correspondence should be addressed at the Amgen Institute, Ontario Cancer Institute, 620 University Avenue, M5G 2C1, Toronto, Ontario, Canada. Telephone: (416) 204-2236. Fax: (416) 204-5300.