Regular ArticleCloning, Structural Analysis, and Chromosomal Localization of the HumanCSRP2Gene Encoding the LIM Domain Protein CRP2☆,☆☆
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Cited by (32)
Molecular cloning, characterization, and expression analysis of the three cysteine and glycine-rich protein genes in the Chinese fire-bellied newt Cynops orientalis
2018, GeneCitation Excerpt :Proteins containing LIM (Lin-11, isl-1, and mec-3) domains play an important role in the cell proliferation and differentiation in many cell types (Dawid et al., 1998; Bach, 2000; Kadrmas and Beckerle, 2004). As a subgroup of the LIM family, the cysteine-rich protein (CRP) family, including CRP1, CRP2, and CRP3 has been identified in various species, such as reptiles, fishes, birds, and mammals (Fung et al., 1995; Weiskirchen et al., 1995; Weiskirchen et al., 1997; Delalande and Rescan, 1998; Henderson et al., 2002). The three CRP family members shared two evolutionarily conserved LIM zinc-finger domains and are essential for muscle cell development and differentiation (Louis et al., 1997; Pomies et al., 1997; Chang et al., 2003; Duan et al., 2003).
Molecular cloning, characterization and tissue specificity of the expression of the ovine CSRP2 and CSRP3 genes from Small-tail Han sheep (Ovis aries)
2016, GeneCitation Excerpt :These proteins have tandem functional LIM zinc-finger domains, each followed by a glycine-rich domain (Louis et al., 1997; Harper et al., 2000), and they regulate gene transcription by binding to specific transcription factors (Weiskirchen et al., 1995; Kirchner et al., 2001). Since the initial identification of CRP2, which was found in a screen looking for genes whose expression patterns were altered in transformed fibroblasts (Weiskirchen and Bister, 1993), and CRP3 in rats (Arber et al., 1994), these proteins have been identified in fishes, birds, mammals and other animals, indicating that CRP2 (Weiskirchen et al., 1995, 1997; Jain et al., 1996; Delalande and Rescan, 1998; Henderson et al., 2002) and CRP3 (Arber et al., 1994; Fung et al., 1995; Harrod et al., 1996) are extensively distributed in eukaryotes. CRP2 protein is encoded by the cysteine- and glycine-rich protein 2 (CSRP2) gene, which plays an important role in the growth and differentiation of smooth muscle.
Rapid detection of CSRP2 mRNA in mouse, rat, and human using LightCycler-based quantitative real-time polymerase chain reaction
2003, Analytical BiochemistryCitation Excerpt :Furthermore, these primers anneal to regions within CSRP2 divergent to other CSRP gene family members, prohibiting the amplification of nucleic acids from other evolutionarily conserved genes (not shown). In order to demonstrate the accuracy of our amplification strategy, we used cDNA templates derived from mouse kidney, primary cultured rat hepatic stellate cells, or the human cell line WI-26 VAA, previously shown to express CSRP2[12,8,13]. The expected 380-bp fragment was detected in each sample (Fig. 1B).
The cysteine- and glycine-rich LIM domain protein CRP2 specifically interacts with a novel human protein (CRP2BP)
2000, Biochemical and Biophysical Research Communications
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Sequence data from this article have been deposited with the GenBank Data Library under Accession Nos. U57646, U72535, U95017, and U95018.
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D. E. RooneyB. H. Czepulkowski, Eds
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To whom correspondence should be addressed at the Institute of Biochemistry, University of Innsbruck, Peter-Mayr-Str. 1a, A-6020 Innsbruck, Austria. Telephone: +43-512-507-5271. Fax: +43-512-507-2894. E-mail: [email protected].