Regular ArticleCloning of the Mouse and Human Solute Carrier 22a3 (Slc22a3/SLC22A3) Identifies a Conserved Cluster of Three Organic Cation Transporters on Mouse Chromosome 17 and Human 6q26–q27☆
References (35)
- et al.
A 2-Mb YAC contig linking the plasminogen-apoprotein(a) gene family to the insulin-like growth factor 2 receptor (IGF2R
Genomics
(1994) - et al.
Basic local alignment search tool
J. Mol. Biol.
(1990) - et al.
Primary structure and functional expression of the apical organic cation transporter from kidney epithelial LLC-PK1 cells
J. Biol. Chem.
(1997) Metabolic interrelationships of placenta and fetus
Placenta
(1995)- et al.
Cloning and functional characterization of a potential-sensitive, polyspecific organic cation transporter (OCT3) most abundantly expressed in placenta
J. Biol. Chem.
(1998) - et al.
The I.M.A.G.E. Consortium: An integrated molecular analysis of genomes and their expression
Genomics
(1996) - et al.
Molecular cloning and characterization of NKT, a gene product related to the organic cation transporter family that is almost exclusively expressed in the kidney
J. Biol. Chem.
(1997) - et al.
Kidney-specific expression of a novel mouse organic cation transporter-like protein
FEBS Lett.
(1997) - et al.
cDNA cloning and functional expression of a novel rat kidney organic cation transporter, OCT2
Biochem. Biophys. Res. Commun.
(1996) - et al.
Characterization of the gene for human plasminogen, a key proenzyme in the fibrinolytic system
J. Biol. Chem.
(1990)
Characterization of the C3 YAC contig from proximal mouse chromosome 17 and analysis of allelic expression of genes flanking the imprinted Igf2r gene
Genomics
Cloning and characterization of a novel human pH-dependent organic cation transporter, OCTN1
FEBS Lett.
The Orct gene ofDrosophila melanogaster
Gene
cDNA sequence, transport function, and genomic organization of human OCTN2, a new member of the organic cation transporter family
Biochem. Biophys. Res. Commun.
Purification of mouse immunoglobulin heavy-chain messenger RNAs from total myeloma tumor RNA
Eur. J. Biochem.
CpG-rich islands and the function of DNA methylation
Nature
Genomic sequencing
Proc. Natl. Acad. Sci. USA
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2024, Biochimica et Biophysica Acta - Molecular Basis of DiseaseOrganic cation transporter 3 mediates the non-norepinephrine transporter driven uptake of meta-[<sup>211</sup>At]astato-benzylguanidine
2022, Nuclear Medicine and BiologyCitation Excerpt :Among the three subtypes of OCTs, OCT1 and 2 are expressed in the major excretory organs: OCT1 is expressed in the liver [16,17], and OCT2 is expressed in the kidney [17]. OCT3 is widely expressed in organs such as the brain, heart, liver, skeletal muscle, prostate, and adrenal gland [18]. OCT3 is thus speculated to be the major transport system of MIBG (other than NETs).
Genomic imprinting of the IGF2R/AIR locus is conserved between bovines and mice
2022, TheriogenologyCitation Excerpt :The Igf2r/Air imprited cluster is located on mouse chromosome 17 and includes three maternally expressed imprinted Igf2r, Slc22a2, Slc22a3 genes, the paternally expressed lncRNA Air [9], and the nonimprinted Slc22a1 gene (Fig. 1). Previously, the mouse Igf2r gene was proposed to be a solo paternally imprinted gene [10,11] and regulated by maternally methylated ICE (named Region2), which is located within intron 2 of the Igf2r gene [12]. ICE acts as the promoter of the paternally expressed antisense lncRNA Air.
Metformin and insulin-resistant related diseases: Emphasis on the role of microRNAs
2021, Biomedicine and PharmacotherapyCitation Excerpt :OCTs have important role in transferring compounds such as catecholamines which also affect the pharmacodynamics of some drugs such as metformin [31,32]. These transporters have three members among which OCT3 is coded by the SLC22A3 gene located on chromosome 6q26-q27 [33]. MiR-147 targets the 3'UTR of SLC22A3 mRNA.
Organic solute carrier 22 (SLC22) family: Potential for interactions with food, herbal/dietary supplements, endogenous compounds, and drugs
2018, Journal of Food and Drug AnalysisCitation Excerpt :OCT3 (SLC22A3). Initially cloned from rat placenta [46], mouse and human orthologs (as well as other species) have been identified [47,48]. OCT3 appears to have the widest tissue distribution among the SLC22 family, including liver, kidney and intestine in humans [42,46,47].
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Sequence data from this article have been deposited with the GenBank Data Library under Accession Nos. AF078748 (1.79-kb 4.3BamHI), AF078750 (completeSlc22a3cDNA), and AF078749 (partialSLC22A3cDNA).
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Present address: Boehringer Ingelheim R&D Vienna, Molecular Biology Department, Dr. Boehringer-Gasse 5-11, A-1121 Vienna, Austria.
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To whom correspondence should be addressed. Telephone: + 31 20 512 2030. Fax: + 31 20 512 2011. E-mail:[email protected].