Elsevier

Genomics

Volume 62, Issue 3, 15 December 1999, Pages 417-426
Genomics

Regular Article
Identification of FLRT1, FLRT2, and FLRT3: A Novel Family of Transmembrane Leucine-Rich Repeat Proteins

https://doi.org/10.1006/geno.1999.6033Get rights and content

Abstract

FLRT1, FLRT2, and FLRT3 comprise a novel gene family isolated in a screen for extracellular matrix proteins expressed in muscle. The three genes encode putative type I transmembrane proteins, each containing 10 leucine-rich repeats flanked by N-terminal and C-terminal cysteine-rich regions, a fibronectin/collagen-like domain, and an intracellular tail. FLRT1 is expressed in kidney and brain, FLRT2 is expressed in pancreas, skeletal muscle, brain, and heart, and FLRT3 is expressed in kidney, brain, pancreas, skeletal muscle, lung, liver, placenta, and heart. FLRT1 localized to 11q12–q13, FLRT2 to 14q24–q32, and FLRT3 to 20p11. When expressed in SF9 and COS-1 cells, FLRT1 and FLRT2 migrate as 90- and 85-kDa proteins, respectively, and both are glycosylated. Given the overall structure of the three proteins, a function in cell adhesion and/or receptor signaling is predicted.

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    Sequence data from this article have been deposited with the EMBL/GenBank Data Libraries under Accession Nos. AF169675–AF169677.

    1

    Current address: Zentrum Kinderheilkunde, Abt. F. Neuropadiatrie, Robert-Koch Strasse 40, 37075 Gottingen, Germany.

    2

    To whom correspondence should be addressed. Telephone: (617) 355-7576. Fax: (617) 355-7588. E-mail: [email protected].

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