Regular ArticleThe Genomic Structure of Human Olfactory Receptor Genes
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2015, Progress in Molecular Biology and Translational ScienceCitation Excerpt :Cloning OR coding sequences from genomic DNA is therefore quite straightforward. The generation of the repertoire of OR genes exhibiting a single coding exon may partly arise from retroposition of OR mRNA in an early evolutionary process.31 OR gene clusters could have resulted from duplication of these ancestral retrogenes.
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2007, Journal of Biological ChemistryCitation Excerpt :Taken together, these data establish the organization of the GPR40 gene, which is comprised of two exons of 24 and 4402 bp separated by a 698-bp intron. This arrangement of a short, non-coding first exon, followed by a long exon containing the complete protein coding information (Fig. 1A), is common in G protein-coupled receptors (32). Characterization of the GPR40 Gene Promoter and Identification of Conserved Regions—Comparison of genomic DNA sequences of different species can often assist in identifying important control elements (33).
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