Regular ArticleA Genome Scan for Loci Associated with Aerobic Running Capacity in Rats
References (46)
Changes in physical fitness and changes in mortality
Lancet
(1998)Chromosomal localization of lipolytic enzymes in the mouse: pancreatic lipase, colipase, hormone-sensitive lipase, hepatic lipase, and carboxyl ester lipase
J. Lipid Res.
(1993)- et al.
The evolution of metabolic cycles
Nature
(1981) Aerobic performance in brothers, dizygotic and monozygotic twins
Med. Sci. Sports Exerc.
(1986)Heritability of adaptive variation
J. Appl. Physiol.
(1971)- et al.
Principles of Exercise Testing and Interpretation: Including Pathophysiology and Clinical Applications
(1999) Genomics, genes, and environmental interaction: the role of exercise
J. Appl. Physiol.
(2000)Genomic scan for maximal oxygen uptake and its response to training in the HERITAGE family study
J. Appl. Physiol.
(2000)- et al.
Finding the molecular basis of quantitative traits: successes and pitfalls
Nat. Rev. Genet.
(2001) Spectrum of aerobic endurance running performance in eleven inbred strains of rats
J. Appl. Physiol.
(1998)
Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results
Nat. Genet.
Functional genomics and rat models
Genome Res.
Genetic analysis of inherited hypertension in the rat
Physiol. Rev.
Artificial selection for intrinsic aerobic endurance running capacity in rats
Physiol. Genomics
Mapping Mendelian factors underlying quantitative traits using RFLP linkage maps
Genetics
Accuracy of mapping quantitative trait loci in autogamous species
Theor. Appl. Genet.
A simple method to calculate resolving power and confidence interval of QTL map location
Behav. Genet.
DNA sequence diversity in a 9.7-kb region of the human lipoprotein lipase gene
Nat. Genet.
Evidence of LPL gene-exercise interaction for body fat and LPL activity: The HERITAGE Family Study
J. Appl. Physiol.
Quantitative trait loci influencing cholesterol and phospholipid phenotypes map to chromosomes that contain genes regulating blood pressure in the spontaneously hypertensive rat
J. Clin. Invest.
A genetic map of the rat derived from recombinant inbred strains
Mamm. Genome
Strategies and potential molecular targets for obesity treatment
Science
Cited by (31)
Cardiovascular research
2019, The Laboratory RatPostnatal training of 129/Sv mice confirms the long-term influence of early exercising on the motor properties of mice
2016, Behavioural Brain ResearchCitation Excerpt :Possible chromosomal locations of regulating genes showed quantitative trait loci (QTL) related to open-maze locomotion [3], open-field activity [4], rotarod performance [5], duration and speed of wheel running [6], and endurance training [7]. One of the QTL involved in the exercise endurance has homologues in rats (D16Rat17) [8], and humans (D13S787, D22S274) [7]. In support of the genetic influence on locomotion, muscle phenotype varies greatly amongst mice strains.
Repeatability of exercise behaviors in mice
2009, Physiology and BehaviorCitation Excerpt :Treadmill testing for assessment of endurance/aerobic capacity in rodents has been generally preferred to swimming tests since rodents do not display consistent swimming behaviors (e.g. animals will bob, float, and/or dive) and these behaviors skew any data investigating aerobic capacity [20]. Several variations of exercise treadmill protocols have been used with rodents [4,18,22,24,25,31,36,39]; however, in the current literature, limited studies report a measure of repeatability of forced treadmill testing within animal [6,17,31]. These studies report within animal repeatability of VO2max measurements, using enclosed treadmill protocols ranging from r = 0.42 to 0.97 [6,17,31].
Comparative Genomics for Detecting Human Disease Genes
2008, Advances in GeneticsCitation Excerpt :To date, there have been more than 2900 published QTL studies in the mouse [according to the Mouse Genome Informatics (MGI) database] (Flint et al., 2005) and 536 QTL papers published with over 1000 QTLs reported for different physiological and pathophysiological traits in the rat. These papers include investigations of the genetic basis of blood pressure (Rapp, 2000), diabetes (Galli et al., 1996; Jacob et al., 1992; Pravenec et al., 1996), cardiovascular disease (Moreno et al., 2003; Stoll et al., 2001), stroke (Rubattu et al., 1996), ethanol preference (Murphy et al., 2002), behavioral conditioning and anxiety (Fernandez‐Teruel et al., 2002; Flint, 2003), fat accumulation (Tanomura et al., 2002), arthritis (Olofsson et al., 2003a), copper metabolism (de Wolf et al., 2002), pituitary tumor growth (Wendell and Gorski, 1997), aerobic capacity (Ways et al., 2002), and chemical carcinogenesis (De Miglio et al., 2002). QTL mapping has been applied to many other organisms as well: zebrafish for QTL mapping of phenotypes with clinical implications such as behavior (Wright et al., 2006); cows for mapping of agriculturally important traits such as milk quality and quantity (Grisart et al., 2002; Malek et al., 2006), which may shed light on fat content and nutrition in human milk; hip dysplasia in dogs (Todhunter et al., 2003) with relevance to human arthritis.
Contribution of Chromosome 14 to Exercise Capacity and Training Responses in Mice
2019, Frontiers in PhysiologyHeritability of endurance traits from animal research models
2019, Routledge Handbook of Sport and Exercise Systems Genetics
- *
To whom correspondence and reprint requests should be addressed. Fax: (419) 383-6168. E-mail: [email protected].