Journal of Molecular Biology
Volume 260, Issue 2, 12 July 1996, Pages 178-195
Regular ArticleIntron-encoded, Antisense Small Nucleolar RNAs: The Characterization of Nine Novel Species Points to Their Direct Role as Guides for the 2′-O-ribose Methylation of rRNAs
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2017, EnzymesCitation Excerpt :These data may suggest that a single nucleoside modification in the rRNAs is essential for the developmental program in zebrafish. In contrast, deletion of four methylation guide snoRNAs (U32a, U33, U34, and U35a [166]) from intronic sequences of Rpl13a gene has no observable consequence on mouse development since live-born mice, obtained at normal Mendelian ratios, are indistinguishable from wild-type mice [167]. However, these mice display altered glucose homeostasis correlated with enhanced insulin secretion, but these phenotypes have been proposed to reflect loss of noncanonical, cytosolic functions of snoRNAs [167], and references therein.
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