Regular ArticleAging Impairs Functional, Metabolic and Ionic Recovery from Ischemia-Reperfusion and Hypoxia-Reoxygenation☆
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Reactive oxygen species production induced by pore opening in cardiac mitochondria: The role of complex III
2017, Journal of Biological ChemistryCitation Excerpt :Alternatively, membrane potential depolarization may increase matrix-free Mg2+ and its release (51). Free Mg2+ elevation after ischemia/reperfusion (52–54) or anoxia/reoxygenation has been well documented (52, 53). Thus, if complex III has become damaged during prolonged ischemia, reperfusion sets the stage for robust continued ROS generation when PTP is open and allows the matrix to equilibrate with elevated cytoplasmic Mg2+ and to activate ME2 at the same time that the NADH/NAD+ ratio is low and ADP is elevated.
Dysfunctional survival-signaling and stress-intolerance in aged murine and human myocardium
2014, Experimental GerontologyCitation Excerpt :This is consistent with the view of declining stress-resistance as a hallmark of cellular aging, however the genesis of this decline remains obscure. Reduced myocardial I–R tolerance is manifested as worsened ionic and energetic imbalances (Headrick, 1998), oxidative-stress (Liu et al., 2004; Oudot et al., 2006), apoptotic activation (Azhar et al., 1999), mitophagy dysregulation (Dutta et al., 2012) and mitochondrial dysfunction (Boengler et al., 2007; Lesnefsky et al., 2006; Marzetti et al., 2013; Pepe et al., 1999). Importantly, these processes are all modulated by cytoprotective signaling paths, whose functionality could influence the aging process itself (Gems and McElwee, 2005; Shore et al., 2012).
Impact of age on long-term outcome after primary angioplasty with bare-metal or drug-eluting stent (from the DESERT Cooperation)
2013, American Journal of CardiologyCitation Excerpt :Consistent with previous reports, we found that patients older than 75 years were more frequently women, with high rates of diabetes mellitus, hypertension, heart failure at presentation, and multivessel disease. Furthermore, several experimental studies have demonstrated that age is associated with greater susceptibility to ischemia-reperfusion injury.12–14 In fact, a previous study showed that age is associated with impaired myocardial perfusion.9
Aldose reductase pathway contributes to vulnerability of aging myocardium to ischemic injury
2011, Experimental GerontologyCitation Excerpt :The presence of inherent metabolic alterations seen in aging animals and humans (Hall et al., 1994; Cartee, 1993; McMillin et al., 1993; Lesnefsky et al., 1994) restricts the availability of therapeutic interventions to protect ischemic myocardium in aging subjects. Impaired metabolism and energy homeostasis have been associated with poor metabolic and functional recovery after I/R in hearts (Kates et al., 2003; Misare et al., 1992; Headrick, 1998). In this context, the relationship between altered glucose metabolism and response to I/R is poorly understood in hearts from aging subjects.
Usefulness of primary angioplasty in nonagenarians with acute myocardial infarction
2010, American Journal of CardiologyBenchmarking Ventricular Arrhythmias in the Mouse-Revisiting the 'Lambeth Conventions' 20 Years On
2008, Heart Lung and Circulation
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Please address all correspondence to: Dr John P. Headrick, Rotary Center for Cardiovascular Research, Griffith University Gold Coast Campus, Southport, QLD 4217, Australia.