Regular ArticleTheengrailedandhuckebeinGenes Are Essential for Development of Serotonin Neurons in theDrosophilaCNS
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Conservation and evolutionary modifications of neuroblast expression patterns in insects
2014, Developmental BiologyCitation Excerpt :NB 7-3 is the only neuroblast that co-expresses hkb and en in D. melanogaster and the only neuroblast that generates the metameric serotonergic neurons in the ventral nerve chord of both D. melanogaster and S. americana (although it is not know whether NB 7-3 expresses hkb in S. americana) (Lundell and Hirsh, 1994; Lundell et al., 1996; Schmid et al., 1999). Loss of either marker results in loss of serotonin expression and pathfinding defects in the NB 7-3 progeny of D. melanogaster (Lundell et al., 1996). If the metameric arrangement of serotonergic neurons is conserved in T. castaneum, the regulatory mechanisms upstream of serotonin must have changed since Tc-hkb and Tc-en are not co-expressed in any neuroblast.
Evolution of the insect terminal patterning system-Insights from the milkweed bug, Oncopeltus fasciatus
2013, Developmental BiologyCitation Excerpt :The original role of hkb may have been in regulating neural development, as might be deduced from its expression pattern in Oncopeltus, in Tribolium and in Clogmia. A possible vestige of this original role is still seen in Drosophila where hkb has a role in the differentiation of serotonin neurons (Lundell et al., 1996). The tsl gene product is an ancient member of a family of pore-forming proteins (Rosado et al., 2008).
Differentiation of the Drosophila serotonergic lineage depends on the regulation of Zfh-1 by Notch and Eagle
2007, Molecular and Cellular NeuroscienceA cell atlas of the larval Aedes aegypti ventral nerve cord
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