Regular ArticleDistinctive Patterns of PDGF-A, FGF-2, IGF-I, and TGF-β1 Gene Expression during Remyelination of Experimentally-Induced Spinal Cord Demyelination
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2022, NeuronCitation Excerpt :In addition, they have been shown to be able to phagocytose myelin debris and have a well-known function in lipid metabolism (Camargo et al., 2017). There is also evidence that astrocytes promote OPC proliferation by the secretion of, for example, PDGF-AA and FGF2, and enhance differentiation by ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and IGF-1 (Messersmith et al., 2000; Deverman and Patterson, 2012; Fischer et al., 2014; Ishibashi et al., 2006; Tsai et al., 2002; Hinks and Franklin, 1999). Moreover, there are inhibitory factors released by astrocytes; in particular, components of the ECM, such as CSPG, hyaluran, or tenascin, but also growth factors with inhibitory functions, including endothelin-1 or FGF 9 (Keough et al., 2016; Lindner et al., 2015; Hammond et al., 2014; Back et al., 2005).
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2021, Progress in NeurobiologyThe Role of Astrocytes in Remyelination
2020, Trends in NeurosciencesCitation Excerpt :Subsequent to this study, it was found that the astrocytic expression of GFAP correlated with the expression of growth factors implicated in OPC maturation. Astrocytes responding to demyelination in the rat spinal cord displayed a similar spatial and temporal profile as PDGF-A, FGF2, transforming growth factor-β (TGF-β), and insulin-like growth factor-1 (IGF-1) [43]. In this study, GFAP mRNA was associated with these growth factors in the recruitment phase of remyelination, whereas at later stages growth factor expression was coupled to areas with low GFAP mRNA expression.
Early Postnatal Expression of Tgfβ-1 and Fgf-2 Correlates With Regenerative Functions of Unrestricted Somatic Stem Cell Infusion After Rabbit GMH-IVH
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