Regular ArticleASP1 (BACE2) Cleaves the Amyloid Precursor Protein at the β-Secretase Site
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Down syndrome, beta-amyloid and neuroimaging
2018, Free Radical Biology and MedicineCitation Excerpt :Further, total APP levels do not appear to change with age despite being higher in DS overall, suggesting that APP overexpression may be the primary driver of Aβ plaque accumulation [24,25]. A protein homologous to BACE 1, BACE2, can also cleave APP at the β-secretase site [26]. BACE-2 is also located on chromosome 21 and may potentially contribute to increased Aβ production in DS.
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