Regular ArticleSoluble Myelin-Associated Glycoprotein Released from Damaged White Matter Inhibits Axonal Regeneration
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2018, Journal of Affective DisordersCitation Excerpt :MAG is localized in the innermost membrane of mature and compact myelin sheaths. Tang et al. demonstrated that soluble MAG could be released into CSF from damaged WM thus inhibiting axonal regeneration in mice (Tang et al., 2001). The expression of MAG was increased in CSF-like fluid in Angiostrongylus cantonensis infected mice and was linked to inflammation-induced immune attack on the myelin sheet (Lin et al., 2010).
Effects of fluoride on synapse morphology and myelin damage in mouse hippocampus
2018, ChemosphereCitation Excerpt :MAG, an inhibitor of nerves system regeneration, naturally exists on the innermost wrap of myelin in both CNS and peripheral nervous system (PNS) (McKerracher and Rosen, 2015). Previous studies demonstrated that high MAG expression occurred after nerve injury (Tang et al., 2001). In CNS diseases like multiple sclerosis, damaged myelin released MAG fragments (Bjartmar and Trapp, 2001).