Regular ArticleDevelopmental Stage-Specific Expression of the α and β Subunits of the HIF-1 Protein in the Mouse and Human Fetus
References (25)
Erythropoietin
Blood
(1991)- et al.
Characterization of hypoxia inducible factor 1 and regulation of DNA binding activity by hypoxia
J Biol Chem
(1993) - et al.
Purification and characterization of hypoxia inducible factor 1
J Biol Chem
(1995) - et al.
Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia inducible-factor
J Biol Chem
(1994) - et al.
Transcriptional regulation of the rat vascular endothelial growth factor gene by hypoxia
J Biol Chem
(1995) - et al.
Regulated basal, inducible and tissue specific human Epo gene expression in transgenic mice requires multiple cis DNA sequences
Blood
(1995) - et al.
Activation of hypoxia-inducible. transcription factor depends primarily upon redox sensitive stabilization of its alpha subunit
J Biol Chem
(1996) - et al.
In vivo expression of mRNAs encoding hypoxia-inducible factor 1
Biochem Biophy Res Commun
(1996) - et al.
Nucleotide sequence, chromosomal assignment and mRNA expression of mouse hypoxia-inducible factor-1α
Biochem Biophys Res Commun
(1996) Erythropoietin
Physiol Rev
(1992)
Liver as a primary site of erythropoietin formation in the fetus
J Lab Clin Med
Studies on the liver to kidney switch of erythropoietin production
J Clin Invest
Cited by (42)
Hypoxia alters the expression of hif-1a mRNA and downstream HIF-1 response genes in embryonic and larval lake whitefish (Coregonus clupeaformis)
2019, Comparative Biochemistry and Physiology -Part A : Molecular and Integrative PhysiologyCitation Excerpt :These findings are consistent with observations in mammals and other fishes. In humans and mice, hif-1α mRNA levels were elevated at 12–22 weeks and 15–19 days, respectively; other gestational ages were not examined (Madan et al., 2002). HIF-1α deficiency was associated with numerous abnormalities in mouse embryos including, but not limited to cardiovascular defects, impairment of angiogenesis, failure of neural tube closure and increased mortality (Iyer et al., 1998).
Impaired Organization of GABAergic Neurons Following Prenatal Hypoxia
2018, NeuroscienceCitation Excerpt :Among the transcription factors strongly associated with hypoxia sensing and the cellular response is Hif1a (Acker and Acker, 2004). Levels of Hif1a in the developing brain are high compared to those in the adult brain (Madan et al., 2002). We observed Hif1a fluorescence in both normoxic and hypoxic cortices.
Critical re-evaluation of neuroglobin expression reveals conserved patterns among mammals
2016, NeuroscienceCitation Excerpt :The comparatively low Ngb expression in early development implies that Ngb is possibly not involved in the known hypoxia tolerance of mammalian fetuses and neonates (Bickler and Donohoe, 2002). Notably, Ngb expression does not peak at birth time, when cellular O2 levels rise approximately fourfold from a relatively hypoxic intra-uterine milieu to the extra-uterine environment, leading to a peak in Hif1α expression (between E15 and D1; (Madan et al., 2002), increased generation of ROS and a compensatory peak in activity of selected antioxidant enzymes (Khan and Black, 2003). This may indicate that Ngb rather does not serve a primary general role in mediating hypoxia tolerance by O2 binding or in ROS defense.
Umbilical cord erythropoietin concentrations and metabolic status in newborns with intrapatum fetal distress
2016, Clinica e Investigacion en Ginecologia y ObstetriciaPharmacologic stabilization of hypoxia-inducible transcription factors protects developing mouse brain from hypoxia-induced apoptotic cell death
2014, NeuroscienceCitation Excerpt :By up-regulation of chemokine receptor 4 (CXCR4) and its physiologic ligand stromal-derived factor-1 (SDF-1), HIF-1 modifies directed neural cell migration (Chu et al., 2008). Second, HIF-dependent endogenous adaptive mechanisms to brain hypoxia are developmentally regulated in a cell-specific manner (Madan et al., 2002; Schneider et al., 2012). Third, suggested by in vitro studies, disturbance of BBB permeability must also be taken into consideration (Chen et al., 2008; Yan et al., 2011).
Developmental study of the distribution of hypoxia-induced factor-1 alpha and microtubule-associated protein 2 in children's brainstem: Comparison between controls and cases with signs of perinatal hypoxia
2014, NeuroscienceCitation Excerpt :After the induction of hypoxia, HIF-1α and vascular endothelial growth factor are spatio-temporally colocalized in the embryo (Lee et al., 2001). HIF-1α is degraded under normal oxygen conditions, but is stabilized under conditions of hypoxia (Chavez et al., 2000; Madan et al., 2002). HIF-1α has been observed under hypoxia (but not under normoxia) in brainstem catecholaminergic neurons located in regions involved in cardiorespiratory control (Pascual et al., 2001).
- 1
To whom correspondence should be addressed at Division of Neonatology, Stanford University School of Medicine, Grant Building, Room S-228, 300 Pasteur Drive, Stanford, CA 94305-5208. Fax: (650) 725-7724. E-mail: [email protected].