Regular ArticleSynelfin Regulation during the Critical Period for Song Learning in Normal and Isolated Juvenile Zebra Finches☆
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Cited by (32)
α-Synuclein and Parkinson's Disease
2010, Blue Books of NeurologyCitation Excerpt :This localization suggests that physiologically αSYN may be involved in synaptic vesicle recycling, storage, and compartmentalization of neurotransmitters, and the regulation of neurotransmitter release. One of the earliest indications in this direction was that its ortholog in birds, called synelfin, has been found to be upregulated developmentally during song learning, a period of particularly high synaptic activity.20 αSYN knockout mice behave grossly normally and display no obvious pathological phenotype, but they show subtle alterations of neurotransmitter release in the basal ganglia under certain experimental conditions in vitro.21
Genes, proteins, and neurotoxins involved in Parkinson's disease
2004, Progress in NeurobiologyCitation Excerpt :Synelfin mRNA has been found to be up-regulated during a critical period of song learning in the lateral magnocellular nucleus of the anterior neostriatum (lMAN) of zebra finches Taeniopygia guttata (George et al., 1995). Interestingly, the synelfin protein is located in the presynaptic terminals from lMAN in the robust nucleus of the archistriatum (Jin and Clayton, 1997), another brain nucleus in birds, which is critically involved in song learning. Since the mammalian α-synuclein is found to be predominately expressed in areas of the adult CNS that display synaptic plasticity, including the cerebral cortex, the hippocampus, the amygdala and the olfactory bulb (Maroteaux and Scheller, 1991; Iwai et al., 1995), it is possible that α-synuclein is also involved in synaptic plasticity in the mammalian brain.
Exposure to Long Chain Polyunsaturated Fatty Acids Triggers Rapid Multimerization of Synucleins
2001, Journal of Biological ChemistryAlpha synuclein aggregation: Is it the toxic gain of function responsible for neurodegeneration in Parkinson's disease?
2001, Mechanisms of Ageing and Development
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G. M. Fiskum, Ed.
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We thank Julia George, Telsa Mittelmier, and Sandy Siepka for useful discussions and critical comments on the paper, and Susan Volman for suggestions on the isolation experiments. This work was supported by NIH Grant NS25742. Address correspondence and reprint requests to Dr. David F. Clayton, B107 Chemical and Life Sciences Lab, 601 S. Goodwin Avenue, Urbana, IL 61801. Fax: (217) 244-1648. E-mail: [email protected].