Brief ReportPosttraining Glucocorticoid Receptor Agonist Enhances Memory in Appetitive and Aversive Pavlovian Discrete-Cue Conditioning Paradigms☆
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2022, NeuroscienceCitation Excerpt :The recruitment of mineralocorticoid (MR) and glucocorticoid (GR) receptors depends on the concentration of glucocorticoids and is driven by receptor’s affinity differences (de Kloet et al., 1993), which can explain their varying effects on memory (Cai et al., 2006; Abrari et al., 2008; Groch et al., 2013; Yang et al., 2013; Amiri et al., 2015; Bueno et al., 2017). Overall, whereas systemic treatment with corticosterone or other agonists potentiates memory consolidation or reconsolidation (Quirarte et al., 1997; Cordero and Sandi, 1998; Zorawski and Killcross, 2002; Hui et al., 2004; Roozendaal et al., 2006a; Tuon et al., 2008; Abrari et al., 2009; Kaouane et al., 2012; Liao et al., 2013; Zalachoras et al., 2013; Xiong et al., 2015), the opposite outcome has been shown after antagonism of MR or GR receptors (Adamec et al., 2007; Taubenfeld et al., 2009; Nikzad et al., 2011). During stressful and emotionally arousing events, endocannabinoid transmission can help maintain the hypothalamic–pituitaryadrenal (HPA) axis homeostasis by buffering basal activity or mediating glucocorticoid fast feedback mechanisms (Di et al., 2003; Patel et al., 2004; Evanson et al., 2010; Hill et al., 2009, 2011; Newsom et al., 2012; for a review, see Morena et al., 2016).
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The authors thank Dr. Etienne Coutureau, Dr. Pam Blundell, and Dr. Vincent Casteras for their support and helpful comments. The work was conducted as part of a Ph.D. thesis (M.Z.) and was supported by an MRC research grant to S.K.
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Address correspondence and reprint requests to Simon Killcross. Fax: +44 29 20874858. E-mail: [email protected].