Regular ArticleThe Basic Domain of the Lentiviral Tat Protein Is Responsible for Damages in Mouse Brain: Involvement of Cytokines
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2021, Neuroscience LettersCitation Excerpt :Among some of the earliest studies, Hayman et al. injected synthetic peptide analogs derived from the basic region of HIV-1 Tat protein into the rat brain and found Tat to be a potent neurotoxin [45]. This was confirmed by another study that also demonstrated that blocking TNF-alpha with pentoxifylline following Tat injection led to decreased IL-1β and iNOS expression that was accompanied by a reduction in the volume of pathological lesions, indicating that the Tat-induced lesions could be likely mediated by TNF-α production [229]. To study the neurotoxicity of HIV-1 proteins gp120 and Tat in the rat striatum, Bansal et al. stereotactically injected recombinant proteins (gp120, Tat, or saline as a negative control) in the striatum of adult male rats.
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