Elsevier

Virology

Volume 248, Issue 2, 1 September 1998, Pages 295-304
Virology

Regular Article
The DF-1 Chicken Fibroblast Cell Line: Transformation Induced by Diverse Oncogenes and Cell Death Resulting from Infection by Avian Leukosis Viruses☆

https://doi.org/10.1006/viro.1998.9290Get rights and content
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Abstract

DF-1 is a continuous cell line of chicken embryo fibroblasts. The cells are free of endogenous sequences related to avian sarcoma and leukosis viruses and have normal fibroblastic morphology. DF-1 cells support the replication of avian retroviruses; diverse oncogenes induce foci of oncogenic transformation on monolayers of DF-1, and avian leukosis viruses of envelope subgroups B, D, and C induce cell death and form plaques. The new cell line will greatly facilitate studies on oncogenic transformation and cell killing by avian viruses.

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☆

M. SingerP. Berg

1

Present address: Institute of Genetics, University of Salzburg, Hellbrunnerstr. 34, 5020 Salzburg, Austria.

2

To whom reprint requests should be addressed. E-mail:[email protected].

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