Elsevier

Virology

Volume 289, Issue 2, 25 October 2001, Pages 186-191
Virology

Rapid Communication
Adenoviral E1A Protein Nuclear Import Is Preferentially Mediated by Importin α3 in Vitro

https://doi.org/10.1006/viro.2001.1151Get rights and content
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Abstract

Nuclear import of some viral proteins depends on importin α proteins. However, no preferences of distinct α-importins for any viral protein import have been demonstrated. We used in vitro import assays and observed that all ubiquitously expressed human importin α isoforms mediate nuclear translocation of adenoviral E1A. Competition with nucleoplasmin suggests that importin α3 is the most efficient import mediator of E1A.

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