Regular ArticleA Physiologically Based Pharmacokinetic Model for Trichloroethylene and Its Metabolites, Chloral Hydrate, Trichloroacetate, Dichloroacetate, Trichloroethanol, and Trichloroethanol Glucuronide in B6C3F1 Mice☆,☆☆
References (60)
- et al.
Quantitative evaluation of the metabolic interactions between trichloroethylene and 1,1-dichloroethylenein vivo
Toxicol. Appl. Pharmacol.
(1987) Pharmacokinetics for regulatory risk analysis: The case of trichloroethylene
Regul. Toxicol. Pharmacol.
(1988)- et al.
Gas chromatographic determination of chloral hydrate, trichloroethanol, trichloroacetic acid in blood and urine employing head-space analysis
J. Chromatogr.
(1974) - et al.
Delineation of the role of metabolism in the hepatotoxicity of trichloroethylene and perchloroethylene: A dose–effect study
Toxicol. Appl. Pharmacol.
(1985) - et al.
Liver tumor induction in B6C3F1 mice by dichloroacetate and trichloroacetate
Toxicology
(1990) - et al.
Physiological pharmacokinetic modeling of inhaled trichloroethylene in rats
Toxicol. Appl. Pharmacol.
(1991) - et al.
Hepatocarcinogenicity of chloral hydrate, 2-chloroacetylaldehyde, and dichloroacetic acid in the male B6C3F1 mouse
Fundam. Appl. Toxicol.
(1992) - et al.
The carcinogenicity of dichloroacetic acid in the male B6C3F1 mouse
Fundam. Appl. Toxicol.
(1991) - et al.
Novel metabolism of trichloroethylene through dechlorination reactions in rats, mice and humans
Biochem. Pharmcol.
(1984) - et al.
Physiologically based pharmacokinetic modeling of the pregnant rat: A multiroute exposure model for trichloroethylene and its metabolite, trichloroacetic acid
Toxicol. Appl. Pharmacol.
(1989)
Physiologically based pharmacokinetic modeling of the lactating rat and nursing pup: A multiroute exposure model for trichloroethylene and its metabolite, trichloroacetic acid
Toxicol. Appl. Pharmacol.
(1990)
Physiologically based pharmacokinetic modeling with trichloroethylene and its metabolite, trichloroacetic acid, in the rat and mouse
Toxicol. Appl. Pharmacol.
(1991)
Partition coefficients of low-molecular-weight volatile chemicals in various liquids and tissues
Toxicol. Appl. Pharmacol.
(1989)
Species differences in response to trichloroethylene. II. Biotransformation in rats and mice
Toxicol. Appl. Pharmacol.
(1985)
The carcinogenicity of trichloroethylene and its metabolites trichloroacetic acid and dichloroacetic acid, in mouse liver
Toxicol. Appl. Pharmacol.
(1987)
A partition coefficient method for non-volatile and intermediate volatility chemicals in biological tissues
Fund. Appl. Tox.
(1994)
Effect of dosing vehicles on the pharmacokinetics of orally administered carbon tetrachloride in rats
Toxicol. Appl. Pharmacol.
(1990)
Metabolism and lipoperoxidation activity of trichloroacetate and dichloroacetate in rats and mice
Toxicol. Appl. Pharmacol.
(1992)
A mechanism for the development of Clara cell lesions in the mouse lung after exposure to trichloroethylene
Chem.–Biol. Interact.
(1992)
Relative formation of dichloroacetate and trichloroacetate from trichloroethylene in male B6C3F1 mice
Toxicol. Appl. Pharmacol.
(1993)
A physiologically based pharmacokinetic model to describe disposition of chloral hydrate and trichloroethanol in mice
Int. Toxicol.
(1995)
Determination of kinetic rate constants for chloral hydrate, trichloroethanol, trichloroacetic acid and dichloroacetic acid: A physiologically based modeling approach
Toxicologist
(1997)
Pharmacokinetic modeling of trichloroethylene and trichloroacetic acid in humans
Risk Anal.
(1993)
Metabolism, toxicity, and carcinogenicity of trichloroethylene
Toxicology
(1989)
Considering pharmacokinetic and mechanistic information in cancer risk assessments for environmental contaminants: Examples with vinyl chloride and trichloroethylene
Chemosphere
(1996)
Disposition and pharmacokinetics of dichloroacetate (DCA) and oxalate following oral DCA doses
Biopharm. Drug Dispos.
(1991)
Consideration of the target organ toxicity of trichloroethylene in terms of metabolite toxicity and pharmacokinetics
Drug Metab. Rev.
(1991)
Absorption, elimination and metabolism of trichloroethylene: A quantitative difference between rats and mice
Xenobiotica
(1986)
Variability in biological monitoring of solvent exposure. I. Development of a population physiological model
Br. J. Ind. Med.
(1989)
Cited by (0)
- ☆
Presented in part at the 35th and 36th Annual Meetings of the Society of Toxicology, Anaheim, CA, 1996 and Cincinnati, OH, 1997, respectively.
- ☆☆
T. R. GerrityC. J. Henry, Eds.
- 2
To whom correspondence should be addressed at AL HSC/OET, Building 79, 2856 G Street, Wright–Patterson AFB, OH 45433–7400. Fax: 513–255–1474.
Copyright © 1997 Academic Press. All rights reserved.